Results 31 to 40 of about 1,258,530 (358)

Path Planning and Collision Avoidance in Unknown Environments for USVs Based on an Improved D* Lite

Applied Sciences, 2021
Path planning and collision avoidance during autonomous navigation in unknown environments is a crucial issue for unmanned surface vehicles (USVs). This paper improves the traditional D* Lite algorithm and achieves multi-goal path planning and collision ...
Xiaohui Zhu, Bin Yan, Yong Yue
doaj   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Formwork material selection and optimization by a comprehensive integrated subjective–objective criteria weighting MCDM model

Discover Materials
Formwork systems account for a considerable cost of a structure because of its labor-intensive nature that needs selection and optimization through an efficient MCDM model.
Tamene Taye Worku
doaj   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Structural and functional characterization of chitinase from carnivorous plant Drosera adelae

FEBS Open Bio, EarlyView.
A class I chitinase from the carnivorous plant Drosera adelae was expressed and purified using a yeast system, revealing high enzymatic activity. Structural analyses of the catalytic and chitin‐binding domains identified key tyrosine residues involved in substrate binding, offering insights into the enzyme's adaptation for insect digestion.
Kazunari Yoneda, Yuki Naruse, Yusaku Suizu, Tomohiro Araki, Yoshikazu Hoshi, Haruhiko Sakuraba, Junji Hayashi, Toshihisa Ohshima   +7 more
wiley   +1 more source

Wazuh SIEM for Cyber Security and Threat Mitigation in Apparel Industries

International Journal of Engineering Materials and Manufacture
Security of IT infrastructure is critical in the modern digital environment, particularly for industries that manufacture clothing. The application of the Wazuh Security Information and Event Management (SIEM) system to improve security monitoring and ...
Md Rafiqul Islam, Raisa Rafique
doaj   +1 more source

Public Demand Oriented Quality Evaluation Model for Rainstorm Disaster Information Disclosure [PDF]

ITM Web of Conferences
By investigating the current situation of information disclosure and public demand during rainstorm disaster in Henan Province, this paper builds a model of factors affecting the quality of information disclosure characterized by rainstorm disaster ...
Yan Tianan, Zhang Yifan, Hua Ruikai
doaj   +1 more source

Post-vaccination adverse reactions, decision regret, and willingness to pay for the booster dose of COVID-19 vaccine among healthcare workers: A mediation analysis

Human Vaccines & Immunotherapeutics, 2022
This study aimed to explore the relationship between post-vaccination adverse reactions, decision regret, and willingness to pay (WTP) for the booster dose. An online survey was conducted in Taizhou, China.
Chengwen Luo, Weicong Jiang, Hai-Xiao Chen, Tao-Hsin Tung   +3 more
doaj   +1 more source

Adipokines and Associations with Incident Osteoporotic Fracture in Patients with Rheumatoid Arthritis

Arthritis Care &Research, Accepted Article.
Purpose We assessed whether circulating adipokines are associated with incident fractures in patients with rheumatoid arthritis (RA). Methods Three adipokines (adiponectin, leptin, fibroblast growth factor [FGF]‐21) were measured using banked enrollment serum from participants in a longitudinal RA cohort.
Joshua F. Baker, Bryant R. England, Michael D. George, Hannah Brubeck, Brian Sauer, Aleksander Lenert, Punyasha Roul, Geoffrey M. Thiele, Ted R. Mikuls, Katherine D. Wysham   +9 more
wiley   +1 more source