Results 41 to 50 of about 1,981,131 (302)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Marketing Management Development for Training Improvement English Learning “Conversation Club”

IJEBD (International Journal of Entrepreneurship and Business Development), 2022
Purpose: The purpose of this research is to find out how to manage marketing, increase the quantity of the “Conversation Club” learning training. Design/methodology/approach: This research approach is quantitative.
Indahwati Indahwati, Ruswiati Suryasaputra, Lusy Tunik Muharlisiani   +2 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Attribute Perception Mapping Services Domestic Airlines Using Correspondence Analysis [PDF]

International Research Journal of Business Studies, 2015
Positioning analysis provides a better understanding of the position based on the perception of passenger flights to service these attributes attached to each airline.
Reni Heviandri Riandarini, Ujang Sumarwan, Kirbrandoko, Lilik Noor   +3 more
doaj  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Impact of COVID-19 on people with non-functioning spleens in Australia

Journal of Infection and Public Health
Background: COVID-19 has had enormous impact on health and social systems, with stringent public health measures enacted across Australia. The virus itself disproportionately affects immunocompromised individuals including people without functioning ...
Maeve Barlow, Penelope Jones, Mihiri Weerasuria, Jessica O’Bryan, Denis Spelman, Ian Woolley   +5 more
doaj   +1 more source

المراسلات السومرية ودورها في توثيق الحياة السياسية والاجتماعية في بلاد الرافدين: دراسة تحليلية في ضوء النصوص المسمارية [PDF]

Maǧallaẗ Kulliyyaẗ Al-ādāb Ǧāmiʿaẗ Būrsaʿīd
استنادًا إلى أن التاريخ لا يمكن أن يُكتب دون وثيقة تبرز الوثائق كمصدر رئيسي لتوثيق الأحداث التاريخية، وتعد المراسلات إحدى أرقى الإبداعات الإنسانية التي استخدمها الإنسان القديم للتواصل وتبادل المعرفة.
حسام محمد عبدالفتاح هلال حجازي
doaj   +1 more source

The Mediterranean Connections of Basque Ports (1700-1841): Trade, Trust and Networks [PDF]

, 2015
[EN] This research analyses the commercial relationships between Basque and the Mediterranean ports from the beginning of the eighteenth century until the first third of the nineteenth century, when the customs were moved to the coast.
Aragón Ruano, Álvaro
core   +1 more source