Results 51 to 60 of about 1,981,131 (302)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
“An appreciative and grateful author”: Edith Wharton and the House of Macmillan [PDF]
, 2005 This essay is the first piece of scholarship to examine the relationship between the expatriate American novelist Edith Wharton (1862-1937) and her chief British publisher, Macmillan and Co.
Towheed, Shafquat
core
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Studia Historica: Historia Moderna, 2020 This article addresses the issue of shipping trade between the American ports of the Philadelphia district and those of New England with Spain, during the turbulent years of the late eighteenth century. First, the US consular network in Spain is analyzed,
Guadalupe CARRASCO GONZÁLEZ
doaj +1 more source
Characterising Web Site Link Structure
, 2007 The topological structures of the Internet and the Web have received considerable attention. However, there has been little research on the topological properties of individual web sites.
Cox, Ingemar +2 more
core +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Correspondence: British Thoracic Society guideline on pulmonary rehabilitation in adults: Does objectivity have a sliding scale? [PDF]
, 2014 This article is made available through the Brunel Open Access Publishing Fund. Copyright © 2014 BMJ Publishing Group Ltd & British Thoracic Society. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non ...
Alison K McConnell +5 more
core +2 more sources
Molecular cancer prevention: Intercepting disease
Molecular Oncology, EarlyView.Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco +2 more
wiley +1 more source
Dificultades del urbanismo comercial: el Plan General de Equipamiento Comercial de Castilla y León [PDF]
Ciudades, 2007 The retail network in Castilla y León has a clear correspondence with the regional urban system, with its weakness and its singularities. The development of new big retail structures and malls, clearly underdeveloped comparing with other Spanish Regions,
Juan Luis de las Rivas Sanz
doaj
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source