Results 131 to 140 of about 468,259 (294)

County and City Health Departments: The Need for Sustainable Funding and the Potential Effect of Health Care Reform on Their Operations [PDF]

open access: yes, 2009
Outlines the role of local health departments, the impact of funding cuts on staff, programs, and services, and the implications for public health.
Jack A. Meyer, Lori Weiselberg
core  

The commercial determinants of maternal health

open access: yesnpj Women's Health
Abstract The burgeoning concept of the commercial determinants of health has not been applied specifically to mothers. We discuss this in terms of acts of both commission and omission. We make recommendations for an overarching ideology in which maternal health is valued as a shared societal responsibility, and bedrock of economic and ...
Mark Hanson   +8 more
openaire   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

open access: yesFEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

open access: yesFEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Longitudinal Study of Salivary Biomarkers in the Definition of Clinico‐Molecular Progression of Parkinson's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
Longitudinal changes in salivary biomarkers in Parkinson’s disease (PD) from early (T0) to 4‐year follow‐up (T1), quantified by ELISA: oligomeric and total α‐synuclein, total and phosphorylated tau, MAP1LC3B (autophagy), and TNFa (inflammation). Blue arrows indicate direction of change at T1 vs T0 (up = increase; down = decrease).
Maria Ilenia De Bartolo   +13 more
wiley   +1 more source

New models and taxonomies to understand and address the commercial determinants of health [PDF]

open access: bronze, 2020
Anna Gilmore   +3 more
openalex   +1 more source

Alleviating transitory food crisis in Africa : international altruism and trade [PDF]

open access: yes
This paper focuses on criticism about the use of emergency food aid in sub-Saharan Africa. More specifically, it examines the response of the donor community to unexpected or transitory drops in domestic food production in 26 countries.
Lavy, Victor
core  

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