Results 91 to 100 of about 2,301,680 (310)
Estrogen and Progesterone Measurement and its Quality Control in Breast Cancer: A Reappraisal
The International Journal of Biological Markers, 1986 This article illustrates the two main methods for routine measurement of cytoplasmic estrogen receptor status in neoplastic biopsy. The first is the Dextran Coated Charcoal Technique (D.C.C.
Adriano Piffanelli +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Nacionalna politika Komunističke partije Jugoslavije na Kosovu i Metohiji 1937-1941. [PDF]
Istorija 20. Veka, 2014 During the Interwar period, Yugoslavia was viewed by the communists as an expression of will of the imperialist forces, that is to say, the product of the World War I.
Dušan Bojković
doaj
Scenarios for land use and food security at global, regional and national scales. [ID812] [PDF]
, 2019 Researchers from Cirad and Inra, with the support of a Scenario Advisory Committee, have carried out an exploratory foresight exercise on 'Land use and food security in 2050' (Agrimonde-Terra) to prepare actors for different possible futures by providing
Brunelle, Thierry +4 more
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Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Participation in higher education: A geodemographic perspective on the potential for further expansion in student numbers [PDF]
, 1998 Higher Education in England has expanded dramatically in the last ten years with the result that currently more than 30 per cent of young people go on to University. This upward trend in the participation rate is almost certain to continue, following the
Batey, Peter, Brown, Peter
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