Results 81 to 90 of about 2,330,129 (358)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Italy towards permanent daylight saving time? Expected benefits for health, climate and society

The Lancet Regional Health. Europe, 2022
Alessandro Miani, Andrea Costa, Michele Emiliano, Nicola Caputo, Annarita Corrado, Manuela Pulimeno, Luigi Gabriele, Luca Levrini, Francesco Schittulli, Prisco Piscitelli   +9 more
doaj   +1 more source

Communication from the Commission to the European parliament, the Council, the European economic and social committee and the committee of the regions. An Integrated Maritime Policy for the European Union

Московский журнал международного права, 2009
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article Editorial
doaj  

The Communication from the Commission to the European Parliament, the Council, the European Economic and Social Committee and the Committee of the Regions: "Towards an EU Criminal Policy: Ensuring the effective implementation of EU policies through criminal law" [PDF]

, 2011

openalex   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Ural Bureau of the Central Committee of the RCP(b) and the Creation of Ural Oblast in 1923

Известия Уральского федерального университета. Серия 2: Гуманитарные науки
This article analyses the activities of the Ural Bureau of the Central Committee of the RCP(b) in the preparation and implementation of measures for the zoning of the Urals within the framework of the administrative-territorial reform of 1923.
Sergey Viktorovich Vorobyov
doaj   +1 more source

Between minority protection and linguistic sovereignty

Revista de Llengua i Dret - Journal of Language and Law, 2018
Twenty-five years after the Charter for Regional or Minority Languages, it is imperative to thoroughly reassess the status of language groups against the background of, first, the massive changes that have taken place in the framework of European ...
Peter A. Kraus
doaj   +1 more source

Cultivating diversity and food quality. Proceedings of Diversifood EU Forum, Brussels, 11 April 2018 [PDF]

, 2018
To tackle this issue, Diversifood team organised a forum with policy makers and stakeholders on the 11th of April 2018, in Brussels. Diversifood’s aim is to share results and key lessons including new approaches for the management of cultivated ...
Bocci, R., Chable, V., Constanzo, A., Drexler, D., Goldringer, I., Oehen, B., Padel, S., Rey, F.   +7 more
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source