Results 61 to 70 of about 2,301,680 (310)

Representing Regions, Challenging Bicameralism: An Introduction

Perspectives on Federalism, 2018
This special issue publishes a number of conference papers presented at the conference ‘Representing Regions, Challenging Bicameralism’ that took place on 22 and 23 March 2018 at the University of Innsbruck, Austria.
Gamper Anna
doaj   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Has VZV epidemiology changed in Italy? Results of a seroprevalence study [PDF]

, 2017
The aim of the study was to evaluate if and how varicella prevalence has changed in Italy. In particular a seroprevalence study was performed, comparing it to similar surveys conducted in pre-immunization era.
Amodio E., Angelillo I., Bagordo F., Baldo V., Baldovin T., Bandettini R., Bassetti D., Bassi C., Bella A., Bernardini S., Binda S., Bonanni P., Bordonaro P., Brignole G., Cacello E., Caligiuri P., Casalino P., Castiglia P., Cia M., Cicerchia E., Clerico L., Cracchiolo M., D'Agaro P., De Donno A., Del Manso M., Devoti G., Di Giuseppe G., Ditommaso S., Fazii P., Gabutti G., Gallo T., Gamper A., Giandomenico A. M., Giraldi C., Grasso G., Greco F., Guerra G., Guido M., Idolo A., Kuhdari P., Lupi S., Maglione F., Manchia P., Megha M., Pagani E., Passamonti B., Pellegrinelli L., Pelliccioni A. R., Perrone M., Peruzzi M., Piana A., Primache V., Renzoni C., Resciniti C., Romano P., Rossi P., Rota M. C., Sammarco M. L., Schettini S., Schippa S., Sciuto V., Segat L., Stefanati A., Sticchi L., Tiscione E., Trucchi C., Tumolo M. R., Vallerini M., Vargiu P., Vitale F., Zizza A., Zotti C.   +71 more
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

The Impact of European Institutions on Local and Regional Development

EIRP Proceedings, 2019
A united Europe is the sum up of how different regions live together and find common perspectives. This does not fit only as a political, social or philosophical idea, but since the creation of the European Union, regional development remains one of ...
Olta Qejvani, Brikena Buda (Dhuli)
doaj  

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

The political secretariats of the Committee of the Regions

, 2023
The literature on the Committee of the Regions (CoR) pays only secondary attention to the political secretariats within the advisory body. The article is based on interviews which reveal that these actors are discreet in the literature, yet discretionary in the political work of the CoR.
  +5 more sources

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

A Tale of Two Europes: European Regions from Berlin to Lisbon

Australian and New Zealand Journal of European Studies, 2010
One of the lesser noted elements of the Lisbon Treaty (and Treaty on a Constitution for Europe that preceded it), was the limited but significant influence that Europe's regions were able to exert of the process. Regional successes at Lisbon included the
W. John Hopkins
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source