Results 81 to 90 of about 2,301,680 (310)
Ural Bureau of the Central Committee of the RCP(b) and the Creation of Ural Oblast in 1923
Известия Уральского федерального университета. Серия 2: Гуманитарные наукиThis article analyses the activities of the Ural Bureau of the Central Committee of the RCP(b) in the preparation and implementation of measures for the zoning of the Urals within the framework of the administrative-territorial reform of 1923.
Sergey Viktorovich Vorobyov
doaj +1 more source
Constraining the Parameters of High-Dimensional Models with Active Learning
, 2019 Constraining the parameters of physical models with $>5-10$ parameters is a widespread problem in fields like particle physics and astronomy. The generation of data to explore this parameter space often requires large amounts of computational resources ...
Caron, Sascha +3 more
core +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
THE PROTECTION OF PERSONAL DATA - AN ESSENTIAL COMPONENT OF THE FUNDAMENTAL HUMAN RIGHTS [PDF]
Challenges of the Knowledge Society, 2019 In terms of human rights in general, and their promotion and protection, especially, developments have been and will continue to remain diverse and complex. This aspect addresses equally the concerns about the identification of human rights, as well as
Augustin FUEREA
doaj
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
The competitiveness of rural areas in the Republic of Tatarstan
Apstract: Applied Studies in Agribusiness and Commerce, 2013 This paper analyses the main factors influencing the regional competitiveness of rural areas in the Tatarstan Republic. Firstly, 19 variables related to the socio-economic situation in the Tatarstan Republic were analysed, these having been taken from ...
Landysh Sitdikova +2 more
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source