Results 111 to 120 of about 14,377,340 (306)

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Leakage Current Mitigation in On-Grid Photovoltaic Systems Using a Flexible Multi-Level Inverter Topology

Eletrônica de Potência
Leakage current is an issue that often causes problems in transformerless grid-connected PV inverters, such as electromagnetic interference, which is conducted or radiated and derates the quality of power injected into the grid.
Caíque C. A. de Carvalho, Paulo R. D. R. da Silva, José M. Araújo, José A. Pomilio   +3 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

An Inductive Probe for the Measurement of Common Mode Currents on Differential Traces

, 2012
Measuring common mode currents on differential microstrip transmission lines is a complicated task, because the common mode current, being the parasitic mode, is usually much weaker than the intended differential current. Hence, the measurement technique
Gang, Li, Pommerenke, David, Victor Khilkevich, Khilkevich, Victor, David Pommerenke, Xu Shuai, Shuai, Xu, Li Gang   +7 more
core   +1 more source

Insulation Condition Assessment in Inverter-Fed Motors Using the High-Frequency Common Mode Current: A Case Study

Energies
The use of the common mode current for stator winding insulation condition assessment has been extensively studied. Two main approaches have been followed.
Mariam Saeed, Daniel Fernández, Juan Manuel Guerrero, Ignacio Díaz, Fernando Briz   +4 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

A topology review and comparative analysis on transformerless grid‐connected photovoltaic inverters and leakage current reduction techniques

IET Renewable Power Generation
Photovoltaic energy source growth is significant in power generation field. Moreover, grid connected inverters strengthen this growth. Development of transformerless inverters with higher efficiency, low cost and size is competitive than the inverters ...
Sahaya Ponrekha A., M. S. P. Subathra, Chokkalingam Bharatiraja, Nallapaneni Manoj Kumar, Hassan Haes Alhelou   +4 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

A Study of the Leakage Current in Transformerless Three-Phase Photovoltaic Inverters Based on the B4 Topology

IEEE Open Journal of Power Electronics
This paper outlines a new solution based on the B4 topology for reducing leakage currents in three-phase, grid-connected photovoltaic inverters. The effectiveness of this topology in reducing leakage currents, which are primarily caused by the relatively
Enric Toran, Marian Liberos, Ivan Patrao, Raul Gonzalez-Medina, Gabriel Garcera, Emilio Figueres   +5 more
doaj   +1 more source