Results 121 to 130 of about 153,833 (299)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel simple wideband common-mode suppression filter

IEICE Electronics Express, 2014
Zeng, Zhibin, Zhuang, Yiqi, Shen, Zengning, Yao, Yindi, Xiang, Xin   +4 more
openaire   +2 more sources

PCB Structures for Common Mode Suppression on Differential Microstrip Lines

, 2014
Common mode noise on differential microstrip lines can be suppressed by PCB embedded filters. These filters are basically resonators, and only the common mode signal can couple to them.
Pommerenke, David, Shuai Xu, Liu, Qian, David Pommerenke, Xu, Shuai, Qian Liu   +5 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Filtering Balanced-to-Single-Ended Power Dividers with Wide Range and High Level of Common-Mode Suppression

, 2019
© 1963-2012 IEEE. A new design approach for developing balanced-to-single-ended (BTSE) power dividers (PDs) to achieve high-level and wide range of common-mode (CM) suppression and minimum mode-conversion level is presented. The suppression of CM signals
Guo, YJ, Lin, JY, Zhu, H
core   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

The suppression of the common mode interference based on the matched transient voltage

Journal of Physics: Conference Series
Abstract This paper presents a new method to suppress the common mode (CM) conducted interference of brushless DC motor (BLDCM). In the proposed method, the effect of the delay on the CM conducted interferences is analyzed and the average output CM voltage is selected as the feedback variable to suppress the CM conducted interference ...
Liwei Sun, Yong Li, Jicheng Zhao, Changwei Mi   +3 more
openaire   +1 more source

Mitigating Common Mode Current in Chain Energy Storage Inverters With Novel Approach

IEEE Open Journal of Power Electronics
The chain energy storage converter, a type of multilevel converter, exhibits characteristics such as multi-modularization, easy scalability, and low harmonic voltage output, rendering it suitable for medium to high voltage and large capacity energy ...
Qinglei Zhang, Waseem Ahmad, Kamran Javed, Ali Raza   +3 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source