Results 111 to 120 of about 153,833 (299)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Multipolar Stimulator for Deep Brain Stimulation With Suppression of Stimulation-Induced Common-Mode Artifacts

IEEE Access
A crucial part of treating neurological disorders like Parkinson’s and epilepsy involves using Deep Brain Stimulation (DBS) systems. This paper describes a system that provides stimulation through a multipolar biphasic current source.
Reza Shokri, Yarallah Koolivand, Omid Shoaei, Daniele D. Caviglia, Orazio Aiello   +4 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Tunable Balanced Bandpass Filter with High Common-mode Suppression Based on SLSRs

, 2017
A tunable balanced bandpass filter (BPF) with a good common-mode (CM) suppression based on slotline resonators is proposed in this letter. Two novel stub-loaded slotline resonators (SLSRs) terminated with varactors are designed to obtain tunable ...
Dun Wei Liao, Feng Wei, Xiao Wei Shi, Xin Yi Wang   +3 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Differential-mode Band-pass Filter with Wideband Behaviour Featuring Intrinsic Common-mode Suppression

This study introduces a differential-mode band-passfilter (BPF) implemented using microstrip topology, specificallydesigned for wideband applications. The introduced filter is designed using branch-line configuration, incorporating input and output (I/O)
Aliqab, Khaled, Daskalakis, Spyridon; id_orcid, Alsharari, Meshari, Armghan, Ammar   +3 more
core   +2 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A Fault Tolerant 3-Phase Adjustable Speed Drive Topology with Common Mode Voltage Suppression [PDF]

, 2015
A fault tolerant adjustable speed drive (ASD) topology is introduced in this work. A conventional ASD topology is modified to address: a) drive vulnerability to semiconductor device faults b) input voltage sags c) motor vulnerability to effects of long ...
Garg, Pawan
core  

Large mode area pixelated trench fiber

, 2014
We propose a novel fiber that offers excellent suppression of higher-order-modes with loss higher than 10dB/m and low loss for fundamental mode (<0.1dB/m) at 1.06µm, with effective area as large as 1100µm2 and excellent bend ...
Baskiotis, C., Deepak Jain, Jayanta K. Sahu, Jain, D., Catherine Baskiotis, Sahu, J.K.   +5 more
core   +1 more source