Results 171 to 180 of about 3,027 (217)

Phenotype‐specific immune profiles and outcomes in childhood autoimmune neutropenia: A 20‐year cohort study

British Journal of Haematology, EarlyView.
Summary Childhood autoimmune neutropenia (AIN) encompasses heterogeneous entities; phenotype‐specific immunological profiles and their relationship to infection outcomes remain incompletely defined. To characterise clinical, immunological and long‐term outcomes across distinct phenotypes of childhood AIN.
Ioanna Saougou, Chrysoula Kosmeri, Nikolaos Chaliasos, Irene Mavroudi, Charalampos Pontikoglou, Alexandros Makis   +5 more
wiley   +1 more source

Auxiliary TARP Subunits Define AMPA Receptor Pharmacology and Function. [PDF]

J Xenobiot
Bdir S, Çapan İ, Hawash M, Servi S, Qneibi M.   +4 more
europepmc   +1 more source

Trust Matters: Examining the Dynamics of Management's Trust in Employee Representation

British Journal of Industrial Relations, EarlyView.
ABSTRACT While trust's relevance in employment relations has been recognised by scholars, empirical studies on management's trust in employee representation are notably scarce. The paper addresses this gap, contributing to a more comprehensive understanding of the dynamics that shape effective dialogue in the employment relationship.
Argyro Avgoustaki, Kabiru Oyetunde, Rea Prouska   +2 more
wiley   +1 more source

Increasing Oligonucleotide Sequencing Information and Throughput with Ion Mobility Spectrometry-Mass Spectrometry. [PDF]

J Am Soc Mass Spectrom
Ryan JP, Slysz GW, Rye P, Stow SM, Dodds JN, Sausen J, Baker ES.   +6 more
europepmc   +1 more source

New biosensors and transgenic mice for multiplex cGMP imaging

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a versatile second messenger that is important for human (patho‐)physiology and pharmacotherapy. Live‐cell imaging of cGMP with biosensors allows to elucidate its spatiotemporal dynamics in real time under close‐to‐native conditions. However, to monitor two separate cGMP pools or cGMP/cAMP
Markus Wolters, Martin Thunemann, Barbara Birk, Susanne Feil, Viacheslav O. Nikolaev, Moritz Lehners, Robert Feil   +6 more
wiley   +1 more source

Proteomics- and BRET- screens identify SPRY2 as a Ras effector that impacts its membrane organization. [PDF]

iScience
Pavic K, Hood FE, Duval CJ, Manoharan GB, Laurini C, Siddiqui FA, Mo SPL, Prior IA, Abankwa DK.   +8 more
europepmc   +1 more source

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

Effects of FGF4/HIF-1α axis-mediated neuronal glycolysis on neuropathic pain. [PDF]

J Headache Pain
Wu Q, Chen Y, Yao X, Ren S, Xie H, Li S, Ying X, Wang X.   +7 more
europepmc   +1 more source

Hypericin Suppresses Liver Cancer Through Autophagic Degradation of AKT and Eliciting Antitumor Immune Response

Cancer Science, EarlyView.
Hypericin induces autophagic AKT degradation by promoting AKT‐HSPA5 interaction in an S473 phosphorylation‐dependent manner, suppressing HCC growth. It enhances CD8+ T cell‐mediated antitumor immunity and synergizes with anti‐PD‐L1 therapy, showing favorable safety for HCC treatment. ABSTRACT Hepatocellular carcinoma (HCC) is the most prevalent primary
Sien Ma, Qianqian Xu, Mengjuan Zhu, Xianming Ge, Jian Xu, Yan Pan, Mengli Wang, Yuting Zhu, Aoxuan Xu, Hanmeng Liu, GuangHai Xiang, Weipeng Gong, Bao Zhao   +12 more
wiley   +1 more source