Results 181 to 190 of about 3,027 (217)

Human T-Lymphotropic Virus Type 1-Associated Myelopathy With Autoimmune Cholangiopathy: An Unusual Immune Conundrum in a Young Patient. [PDF]

Case Rep Infect Dis
Saad A, Jadoon Y, Sabir R.
europepmc   +1 more source

YBX1 Promotes Malignant Progression of HNSCC via Stabilizing NSUN2‐m5C Modified ATF4 mRNA

Cancer Science, EarlyView.
The diagram depicts the core axis and the key finding: “Targeting YBX1/NSUN2 abrogates HNSCC progression”. Within left‐sided HNSCC cells, NSUN2 mediates m5C methylation on the CDS of ATF4 mRNA; YBX1 then specifically recognizes and binds this modified site, augmenting ATF4 mRNA stability, which ultimately promotes cancer cell proliferation, migration ...
Yanwei Li, Shuang Li, Yang Li, Zhanyu Pan   +3 more
wiley   +1 more source

An aerosolized dual-action autotaxin inhibitor-PPARγ agonist for the treatment of pulmonary fibrosis. [PDF]

Cell Rep Med
Matralis AN, Stylianaki EA, Ladopoulou EM, Kanellopoulou P, Smyrniotis S, Magkrioti C, Papavasileiou KD, Willems S, Rincon Pabon JP, Nastos D, Galaras A, Moro C, Dedos SG, Kaffe E, Hatzis P, Osman-Ponchet H, Merk D, Politis A, Afantitis A, Tseti I, Antoniou KM, Wells AU, Aidinis V.   +22 more
europepmc   +1 more source

Proton-selective conductance and gating of the lysosomal cation channel TMEM175. [PDF]

Proc Natl Acad Sci U S A
Schulze T, Sprave T, Groebe C, Hendrik Krumbach J, Behringer M, Bazzone A, Zerlotti R, Fertig N, Althaus M, Hamacher K, Thiel G, Grimm C, Rauh O.   +12 more
europepmc   +1 more source

Lactate‐Primed NETosis Modulates Hepatic Regeneration During Acute Liver Failure via the TLR9/KLF15/AJUBA Axis

Cell Proliferation, EarlyView.
This study elucidates a novel Kupffer cell‐neutrophil‐hepatocyte axis that drives metabolic‐immune crosstalk during acute liver failure. Specifically, lactate‐primed NETs release links metabolic reprogramming to NETosis‐induced regenerative failure in hepatocytes via the TLR9/KLF15/AJUBA axis.
Jin Guo, Xiaoya Zhang, Danmei Zhang, Chunxia Shi, Luwen Wang, Zuojiong Gong   +5 more
wiley   +1 more source

Computational Investigation of Novel pUL56 Ligands Using Docking and Molecular Dynamics with Preliminary Cytotoxicity Evaluation: An Early-Stage Study. [PDF]

Molecules
Feoktistova V, Afolabi SO, Klabukov AM, Shtro AA, Kolobov AV, Baichurin RI, Skorb EV, Shityakov S.   +7 more
europepmc   +1 more source

PLIN5 Protects Against Ang II‐Induced Podocyte Lipotoxicity by Interacting With FKBP8 and Preserving Lipid Droplet–Mitochondria Contact

Cell Proliferation, EarlyView.
PLIN5‐FKBP8 tethers lipid droplets to mitochondria to counteract Ang II‐induced lipotoxicity. ABSTRACT Chronic kidney disease (CKD) remains a major global health challenge. Angiotensin II (Ang II)‐induced lipotoxicity is an important contributor to podocyte injury.
Ping Wang, Wenjie Chen, Jingjing Ke, Hongtu Hu, Zhuan Peng, Yue Qi, Guohua Ding, Jijia Hu   +7 more
wiley   +1 more source

Intrinsic resistance to RAS inhibitors is driven by dysregulation of KRAS degradation. [PDF]

Nat Commun
Ivanisevic T, Ma Y, Van Boxel E, Magits W, Lechat B, Koçberber Z, Willnow P, Fendt SM, Velde GV, Sewduth R, Sablina AA.   +10 more
europepmc   +1 more source

Clinical and genetic characterization of intellectual disability

Developmental Medicine &Child Neurology, EarlyView.
This study examines the etiological factors and comorbidities in a large cohort of Finnish patients with intellectual disability. Genetic causes—including chromosomal abnormalities and pathogenic gene variants—were more frequently identified in individuals with moderate to profound intellectual disability.
Aarni Venetvaara, Minna Kraatari‐Tiri, Jussi‐Pekka Tolonen, Marko Merikukka, IDGEN Study Group, Hannaleena Kokkonen, Teija Paakkola, Susanna Varis, Antti Dahl, Jarmo Körkkö, Jonna Komulainen‐Ebrahim, Jukka Moilanen, Johanna Uusimaa, Outi Kuismin, Elisa Rahikkala   +14 more
wiley   +1 more source

Pharmacological administration of FGF21 reverses obesity through a parabrachial-projecting neuron population in the hindbrain. [PDF]

Cell Rep
Lin Y, Claflin KE, Aklan I, Morgan DA, Sullivan AI, Rudolph MC, Rahmouni K, Potthoff MJ.   +7 more
europepmc   +1 more source