Results 41 to 50 of about 954,905 (286)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
One size fits all? Designer-institutions: Lessons from two flawed attempts in Malawi
International Journal of the Commons, 2010 This article observes two examples of attempted institutional design in Malawi's central region, Kasungu. In both cases external development actors enter local communities, and establish infrastructure to exploit two common sources of water.
Tomas Moe Skjølsvold
doaj +1 more source
Ecology and Society, 2022 The state of Nebraska, USA employs a localized, integrated approach to managing water resources to address escalating quantity challenges. Here, we assess differences between agricultural water users’ perceptions of water management in a water-stressed ...
Mark E Burbach +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
International Journal of the Commons, 2015 Our study focuses on pasture reform in Azerbaijan within the context of transition and pasture reform in Central Asian and Caucasian countries. Despite the rapid emergence of individualised rights for pasture plots, which is an exceptional development in
Regina Neudert +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
International Journal of the Commons, 2011 This paper analyses the international regime governing the use of broadcasting frequencies in the long and medium wave bands in Europe from 1950 until 1970.
Christian Henrich-Franke
doaj +1 more source
Prices versus Quantities for Common Pool Resources [PDF]
, 2001 In Weitzman (1974) the choice between price and quantity regulation under imperfect information is analysed. It is shown that the choice between the two regulatory instruments depends on the sign of the sum of the curvatures of the cost and benefit ...
Jensen, Frank
core
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
The role of institutions in community wildlife conservation in Zimbabwe
International Journal of the Commons, 2018 Institutions play a significant role in stabilizing large-scale cooperation in common pool resource management. Without restrictions to govern human behaviour, most natural resources are vulnerable to overexploitation.
Herbert Ntuli, Edwin Muchapondwa
doaj +1 more source