Results 41 to 50 of about 9,416,735 (293)
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Governing a Common-Pool Resource in a Directed Network [PDF]
SSRN Electronic Journal, 2010 A local public-good game played on directed networks is analyzed. The model is motivated by one-way flows of hydrological influence between cities of a river basin that may shape the level of their contribution to the conservation of wetlands. It is shown that in many (but not all) directed networks, there exists an equilibrium, sometimes socially ...
Lionel Richefort, Patrick Point
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Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
One size fits all? Designer-institutions: Lessons from two flawed attempts in Malawi
International Journal of the Commons, 2010 This article observes two examples of attempted institutional design in Malawi's central region, Kasungu. In both cases external development actors enter local communities, and establish infrastructure to exploit two common sources of water.
Tomas Moe Skjølsvold
doaj +1 more source
Ecology and Society, 2022 The state of Nebraska, USA employs a localized, integrated approach to managing water resources to address escalating quantity challenges. Here, we assess differences between agricultural water users’ perceptions of water management in a water-stressed ...
Mark E Burbach +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
The distributional impact of common‐pool resource regulations [PDF]
Indian Growth and Development Review, 2011 PurposeRegulating common‐pool resources is welfare enhancing for society but not necessarily for all users who may therefore oppose regulations. The purpose of this paper is to examine the short‐term impact of common‐pool resource regulations on welfare distribution.Design/methodology/approachThe authors model a game of common‐pool resource extraction ...
Ambec, Stefan, Sebi, Carine
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International Journal of the Commons, 2015 Our study focuses on pasture reform in Azerbaijan within the context of transition and pasture reform in Central Asian and Caucasian countries. Despite the rapid emergence of individualised rights for pasture plots, which is an exceptional development in
Regina Neudert +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
International Journal of the Commons, 2011 This paper analyses the international regime governing the use of broadcasting frequencies in the long and medium wave bands in Europe from 1950 until 1970.
Christian Henrich-Franke
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