Results 91 to 100 of about 249,829 (331)
Advanced Science, EarlyView.Liver fibrosis is a growing global health burden with no specific treatment. HSC activation is the predominant driver of liver fibrogenesis and the current focus in antifibrotic drug discovery. This study identifies autocrine GDF10 activates BMPR2/ALK3‐SMAD1/5/8‐SMAD7 pathway to counteract the TGF‐β‐SMAD2/3 pathway in HSCs, thereby inhibiting HSC ...
Yinliang Zhang +16 more
wiley +1 more source
Advanced Science, EarlyView.Using the MOSTtechnology and whole‐liver Nissl staining method, a multi‐structural 3D pathological panorama of liver fibrosis is obtained. The damaged sinusoids, steatotic hepatocytes, and collagen deposition are all concentrated in pericentral areas.
Xiaochuan Zhang +13 more
wiley +1 more source
The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression
Hepatology, EarlyView., 2022 Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro +14 more
wiley +1 more source
“Wait-and-See” Strategy for Asymptomatic Patients with Common Bile Duct Stones
The Korean Journal of Gastroenterology, 2022 Yoon Suk Lee
doaj +1 more source
Presence of choledocholithiasis in patients undergoing cholecystectomy for mild biliary pancreatitis
Journal of Society of Surgeons of Nepal, 2016 Introduction: Standard recommendations for patients recovering from an episode of biliary pancreatitis include cholecystectomy with intra operative cholangiogram or ERCP during the same hospital admission as it is believed that the instigating factor is ...
S Pradhan, S Shah, S Maharjan, JN Shah
doaj +1 more source
Bile acids trigger cholemic nephropathy in common bile‐duct–ligated mice
Hepatology, 2013 Tubular epithelial injury represents an underestimated but important cause of renal dysfunction in patients with cholestasis and advanced liver disease, but the underlying mechanisms are unclear.
P. Fickert +17 more
semanticscholar +1 more source
Hepatology, EarlyView., 2022 Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro +17 more
wiley +1 more source
Endoscopic management of difficult common bile duct stones.
World Journal of Gastroenterology, 2013 Endoscopy is widely accepted as the first treatment option in the management of bile duct stones. In this review we focus on the alternative endoscopic modalities for the management of difficult common bile duct stones. Most biliary stones can be removed
G. Trikudanathan +2 more
semanticscholar +1 more source
Hepatology, EarlyView., 2022 Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong +9 more
wiley +1 more source
JLUMHS, 2020 OBJECTIVE: To evaluate the diagnostic ability of sonographic Common bile duct (CBD) dilation in the presence or absence of laboratory abnormalities for the diagnosis of complicated biliary pathology.
Dr. Summaya Saeed +5 more
doaj +1 more source