Results 61 to 70 of about 366,599 (355)

An alternative surgical approach reduces variability following filament induction of experimental stroke in mice

Disease Models & Mechanisms, 2017
Animal models are essential for understanding the pathology of stroke and investigating potential treatments. However, in vivo stroke models are associated, particularly in mice, with high variability in lesion volume.
Melissa Trotman-Lucas, Michael E. Kelly, Justyna Janus, Robert Fern, Claire L. Gibson   +4 more
doaj   +1 more source

ATF5‐Dependent GDF15 Expression Mediates Anesthesia‐Induced Neuroprotection Against Stroke

Advanced Science, EarlyView.
Anesthesia‐induced preconditioning protects against perioperative stroke. By manipulating ATF5 in excitatory neurons, it is shown that anesthesia‐driven ATF5 upregulation activates the mitochondrial unfolded protein response (UPRmt) and elevates GDF15 expression.
Xianshu Ju, Tao Zhang, Jianchen Cui, Yulim Lee, Suho Lee, Ho Min Kim, Boohwi Hong, Jiho Park, Chul Hee Choi, Hyon‐Seung Yi, Jun Young Heo, Woosuk Chung   +11 more
wiley   +1 more source

Effects of external irradiation of the neck region on intima media thickness of the common carotid artery

Cardiovascular Ultrasound, 2010
BackgroundSeveral studies have shown that common carotid intima-media thickness (IMT) is increased after radiotherapy (RT) to the head and neck. However, further studies are needed to define the exact mechanism of radiation-induced injury in large ...
M. E. Gianicolo, Emilio Antonio Luca Gianicolo, F. Tramacere, M. Andreassi, Maurizio Portaluri   +4 more
semanticscholar   +1 more source

Endothelial BMP6 Drives Hemodynamic‐Dependent VSMCs Calcification in Carotid Atherosclerosis

Advanced Science, EarlyView.
The study demonstrates that endothelial cell (EC)‐derived BMP6 promotes the osteogenic differentiation of vascular smooth muscle cells (VSMCs) through cell‐cell interactions. Additionally, the researchers preliminarily explore the driving effect of hemodynamic factors on BMP6‐induced calcification and reveal the regulatory role of KLF4 on BMP6.
Shen Li, Shuang Cao, Peipei Li, Feng Zhang, Gangfeng Ren, Xin Wang, Jiawei Zhao, Chen Liu, Yuan Gao, Jie Xu, Yongjun Wang, Zongping Xia, Yuming Xu   +12 more
wiley   +1 more source

Incidence of carotid artery stenosis in acute ischemic stroke at BMC Hospital Quetta [PDF]

Romanian Journal of Neurology
Background and objectives. This study aimed to explore the prevalence, severity, and distribution of carotid artery stenosis among patients experiencing ischemic strokes. Materials and methods.
Muhammad Essa, Amanullah Kakar, Gul Andam, Noor Ahmed Khoso, Muhammad Saleem, Noman ul Haq, Anjum Farooq, Wazir Akber, Ihsan ul Haq, Paras Laraib, Shafqat Shahzad   +10 more
doaj   +1 more source

A Patient‐Derived Organoid Biobank of Adamantinomatous Craniopharyngioma as a Platform for Drug Discovery

Advanced Science, EarlyView.
This study successfully establishes adamantinomatous craniopharyngioma (ACP) patient‐derived organoids (PDOs) that preserve the histopathological and genetic features of the original tumors. Through drug sensitivity assays and subsequent mechanistic analyses, the study demonstrates that Ceritinib exerts its inhibitory effects on ACP PDO growth by ...
Huarong Zhang, Chaohu Wang, Jun Fan, Zexin Chen, Haoying Yu, Yawen Bai, Tingcheng Zhang, Qianchao Zhu, Yiwen Feng, Peirong Niu, Jiaqian Chen, Liping Yang, Xueying Li, Lei Yu, Songtao Qi, Yi Liu   +15 more
wiley   +1 more source

Temporary Occlusion of Common Carotid Arteries Does Not Evoke Total Inhibition in the Activity of Corticospinal Tract Neurons in Experimental Conditions [PDF]

, 2023
Agnieszka Szymankiewicz-Szukała, Juliusz Huber, Piotr Czarnecki, Agnieszka Wiertel-Krawczuk, Mikołaj Dąbrowski   +4 more
openalex   +1 more source

Iron Overload Mediates the Differential Cell Fate of Astrocytes from Neurons and Its Regulatory Mechanisms in Ischemic Stroke

Advanced Science, EarlyView.
Upon ischemia/reperfusion‐induced iron overload condition, neurons and astrocytes exhibit similar oxidative stress changes but opposite alterations in endogenous antioxidant defense mechanisms, leading to divergent ferroptotic outcomes. The iron deposition and neuronal loss are increased within the perilesional cortex of stroke patients ...
Yi Guo, Yue Wang, Yong Ni, Bin Bo, Jinzhi He, Yongming Zhu, Aiping Qin, Xianyong Zhou, Huaping Du, Yuan Liu, Tianyao Wang, Yudu Li, Yibo Zhao, Zengai Chen, Zhipei Liang, Yao Li, Yuan Xu, Huiling Zhang   +17 more
wiley   +1 more source

Two Cases Treated by Different Strategies for Common Carotid Artery Dissection with Thrombosis Due to a Type A Aortic Dissection

Brazilian Journal of Cardiovascular Surgery
Total arch replacement and stent trunk were performed for two patients. One of these underwent a total bilateral carotid artery replacement in anatomical position while the other underwent partial carotid artery dissection. The first patient demonstrated
Wei Ren, Feng Shi, Zhiwei Wang, Jiahui Wang, Jinxing Chang   +4 more
doaj   +1 more source

Low prevalence of significant carotid artery disease in Iranian patients undergoing elective coronary artery bypass

Cardiovascular Ultrasound, 2007
Background Coronary artery bypass grafting ranks as one of the most frequent operations worldwide. The presence of carotid artery stenosis may increase the stroke rate in the perioperative period.
Karimi Fatemeh, Farhoodi Mehdi, Afrasyabi Abbas, Tarzamni Mohammad K, Farhang Sara   +4 more
doaj   +1 more source