Results 101 to 110 of about 2,477,472 (306)
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
Computing and testing a stable common currency for Mercosur countries [PDF]
This paper develops a stable common currency for mid-sized open monetary economies with incomplete markets in general and the Mercosur countries in particular. The proposed currency is constructed as a derivative of a dynamic portfolio of securities that
Ariel M. Viale +3 more
core
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
High Robustness Requirements in a Common Criteria Protection Profile [PDF]
, 2006 The development of a Common Criteria protection profile for high-robustness separation kernels requires explicit modifications of several Common Criteria requirements as well as extrapolation from existing (e.g., medium robustness) guidance and decisions.
Levin, Timothy E. +2 more
core
The Common Criteria and Information Systems Security Certification
, 2023 Information security is a vital business requirement in today’s information systems (IS). Last decades, the prospect of information technology security evaluation became a great worldwide challenge for many national institutes, agencies and schemes ...
Maditinos, Dimitrios +3 more
core
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Chain of Trust: Unraveling References Among Common Criteria Certified Products
International audienceWith 5394 security certificates of IT products and systems, the Common Criteria for Information Technology Security Evaluation have bred an ecosystem entangled with various kind of relations between the certified products.
Chmielewski, Łukasz +4 more
core +2 more sources
The common good of the company and the theory of organization [PDF]
The concept of common good occupies a prominent place in political and social philosophy, yet it has had little impact on the theory of the firm. This is despite some recent attempts to resituate the theory of the firm on broader and therefore more ...
Argandoña, Antonio
core
Using Common Criteria Methodology to Express Informal Security Requirements [PDF]
, 2006 Often, security requirements for complex systems are hard to discern because it is difficult to determine which requirements must be allocated to the system and which pertain to the system environment.
Kane, Douglas R. +2 more
core