Results 81 to 90 of about 2,578,328 (266)

An international Delphi consensus process to determine a common data element and core outcome set for frailty: FOCUS (The Frailty Outcomes Consensus Project)

BMC Geriatrics, 2022
Background Despite increased recognition of frailty and its importance, high quality evidence to guide decision-making is lacking. There has been variation in reported data elements and outcomes which makes it challenging to interpret results across ...
Jeanette C. Prorok, Paula R. Williamson, Beverley Shea, Darryl Rolfson, Leocadio Rodriguez Mañas, Matteo Cesari, Perry Kim, John Muscedere   +7 more
doaj   +1 more source

Standard Definitions and Common Data Elements for Clinical Trials in Patients With Alcoholic Hepatitis: Recommendation From the NIAAA Alcoholic Hepatitis Consortia.

Gastroenterology, 2016
Heavy drinkers are at risk for a spectrum of histologic alcohol-related liver injury: steatosis, alcoholic steatohepatitis (ASH), alcohol-related fibrosis, and cirrhosis.
D. Crabb, R. Bataller, N. Chalasani, P. Kamath, M. Lucey, P. Mathurin, C. McClain, A. McCullough, M. Mitchell, T. Morgan, L. Nagy, S. Radaeva, A. Sanyal, V. Shah, G. Szabo   +14 more
semanticscholar   +1 more source

Common Data Elements for Research on Traumatic Brain Injury: Pediatric Considerations [PDF]

Journal of Neurotrauma, 2012
Traumatic brain injury (TBI) is a significant global health problem, with a notably high incidence in children and adolescents. Despite the prevalence of TBI and the disabilities that often follow, research on which to base effective treatment is limited by several challenges, including but not limited to the complexity and heterogeneity of TBI.
Joanne Odenkirchen, Ann-Christine Duhaime, Ramona Hicks, A. Cate Miller   +3 more
openaire   +3 more sources

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

FEBS Letters, EarlyView.
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga, Kazuki Harada, Takuya Yamauchi, Tetsuya Kitaguchi, Masami Yokota Hirai, Mitsuharu Matsumoto, Takashi Tsuboi   +6 more
wiley   +1 more source

RE-CODE DCM (REsearch Objectives and Common Data Elements for Degenerative Cervical Myelopathy): A Consensus Process to Improve Research Efficiency in DCM, Through Establishment of a Standardized Dataset for Clinical Research and the Definition of the Research Priorities

Global Spine Journal, 2019
Study Design: Mixed-method consensus process. Objectives: Degenerative cervical myelopathy (DCM) is a common and disabling condition that arises when mechanical stress damages the spinal cord as a result of degenerative changes in the surrounding spinal ...
B. Davies, D. Khan, O. Mowforth, A. McNair, T. Gronlund, A. Kolias, Lindsay A. Tetreault, M. Starkey, Iwan Sadler, Ellen Sarewitz, Delphine Houlton, Julia Carter, Sukhvinder Kalsi-Ryan, B. Aarabi, B. Kwon, S. Kurpad, J. Harrop, Jefferson R. Wilson, Robert G. Grossman, A. Curt, M. Fehlings, M. Kotter   +21 more
semanticscholar   +1 more source

Study Data Element Mapping: Feasibility of Defining Common Data Elements Across COVID-19 Studies [PDF]

, 2020
Background: Numerous clinical studies are now underway investigating aspects of COVID-19. The aim of this study was to identify a selection of national and/or multicentre clinical COVID-19 studies in the United Kingdom to examine the feasibility and outcomes of documenting the most frequent data elements common across studies to rapidly inform future ...
Mathewson, Priscilla, Gordon, Ben, Snowley, Kay, Fennessy, Clara, Denniston, Alastair, Sebire, Neil   +5 more
openaire   +2 more sources

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Feasibility of Combining Common Data Elements Across Studies to Test a Hypothesis [PDF]

Journal of Nursing Scholarship, 2017
AbstractPurposeThe purpose of this article is to describe the outcomes of a collaborative initiative to share data across five schools of nursing in order to evaluate the feasibility of collecting common data elements (CDEs) and developing a common data repository to test hypotheses of interest to nursing scientists.
Cynthia M. Dougherty, Margaret M. Heitkemper, Carol M. Musil, Shirley M. Moore, JoAnne D. Whitney, Patricia A. Grady, Donald E. Bailey, Donna Jo McCloskey, Drenna Waldrop-Valverde, Susan G. Dorsey, Sharron L. Docherty, Andrea Plotsky, Elizabeth J. Corwin, Joan K. Austin   +13 more
openaire   +2 more sources