Results 151 to 160 of about 8,566,693 (290)

Kineret: Israel's Largest Hospital Network Transformed into the OMOP common data model for collaborative research. [PDF]

PLoS One
Rappoport N, Livne G, Perry Cohen N, Makover N, Eshel-Geva H, Kapach H, Hadad T, Alon Y, Rubin R, Chai S, da Villa S, Hochman O.   +11 more
europepmc   +1 more source

CHRONICLE Data Model and Common Data Environment

The purpose of this deliverable will be twofold i.e., (i) to document the building Digital Twin (DT) data model capable to capture all data requirements for the digital representation of buildings, their operations and the information required for building performance assessment and certification and; (ii) to demonstrate the CHRONICLE Common Data ...
openaire   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

SEA CDM: Study-Experiment-Assay Common Data Model and Databases for Cross-Domain Data Integration and Analysis. [PDF]

Sci Data
Huffman A, Yeh FY, Hur J, Zheng J, Masci AM, Wu G, Tao C, Athey B, He Y.   +8 more
europepmc   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Exploring common data model coverage of nursing flowsheet data: a pilot study using SNOMED CT and LOINC mapping. [PDF]

JAMIA Open
Austin R, Britt Lalich M, Stewart K, Zarbano J, Byrne M, Pinto MD, Umberfield EE.   +6 more
europepmc   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Establishing standards: harmonising coding principles for a minimal cancer dataset in the OMOP Common Data Model. [PDF]

ESMO Real World Data Digit Oncol
Ajmal A, Bouissou O, Brash J, Cheeseman S, Banduge PG, Gomes AL, Revie L, Ross E, Theophanous S, Thonnard J, Van Maanen A, Vengadeswaran A, Wolf A, Fernandez XM.   +13 more
europepmc   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Association Between Persistent Treatment of Alzheimer's Dementia and Osteoporosis Using a Common Data Model. [PDF]

Dement Neurocogn Disord, 2023
Hwang S, Soung YG, Kang SU, Yu D, Baek H, Jang JW.   +5 more
europepmc   +1 more source