Results 181 to 190 of about 8,566,693 (290)

Expanding the OMOP Common Data Model to Support Perinatal Research in Network Studies. [PDF]

Pharmacoepidemiol Drug Saf
Abellan A, Burn E, Trinh NTH, Burkard T, Callahan A, Fernández-Bertolín S, Hurley E, Rodriguez C, Segundo E, Morales DR, M E Nordeng H, Duarte-Salles T.   +11 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Pretrained patient trajectories for adverse drug event prediction using common data model-based electronic health records. [PDF]

Commun Med (Lond)
Kim J, Kim JS, Lee JH, Kim MG, Kim T, Cho C, Park RW, Kim K.   +7 more
europepmc   +1 more source

SatisFactory Common Information Data Exchange Model

This report will deal with the detailed specifications of the Common Information Data Exchange Model. It will be a living document with two revisions foreseen in M16 and M28.
openaire   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

An ontology-based rare disease common data model harmonising international registries, FHIR, and Phenopackets. [PDF]

Sci Data
Graefe ASL, Hübner MR, Rehburg F, Sander S, Klopfenstein SAI, Alkarkoukly S, Grönke A, Weyersberg A, Danis D, Zschüntzsch J, Nyoungui EF, Wiegand S, Kühnen P, Robinson PN, Beyan O, Thun S.   +15 more
europepmc   +1 more source

D2.3-Common data models for energy

D23 PLATOON common data models for energy M12 ...
openaire   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Implementing Cancer Registry Data With the PCORnet Common Data Model: The Greater Plains Collaborative Experience. [PDF]

JCO Clin Cancer Inform
McDowell BD, O'Rorke MA, Schroeder MC, Chrischilles EA, Spinka CM, Waitman LR, Anuforo K, Araya A, Bah H, Barlocker J, Chandaka S, Cowell LG, Geary CR, Gupta S, Horne BD, Knosp BM, Lai AM, Mandhadi V, Mohammad Mosa AS, Reeder P, Ryu G, Shukwit B, Smith C, Stoddard AJ, Syed M, Syed S, Taylor BW, VanWormer JJ.   +27 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source