Results 81 to 90 of about 8,566,693 (290)

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Improving the Diagnosis of Systemic Lupus Erythematosus with Machine Learning Algorithms Based on Real-World Data

Mathematics
This study addresses the diagnostic challenges of Systemic Lupus Erythematosus (SLE), an autoimmune disease with a complex etiology and varied symptoms.
Meeyoung Park
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Transforming the Information System for Research in Primary Care (SIDIAP) in Catalonia to the OMOP Common Data Model and Its Use for COVID-19 Research

Clinical Epidemiology, 2023
Berta Raventós,1,2,* Sergio Fernández-Bertolín,1,* María Aragón,1 Erica A Voss,3– 5 Clair Blacketer,3– 5 Leonardo Méndez-Boo,6 Martina Recalde,1 Elena Roel,1,2 Andrea Pistillo,1,7 Carlen Reyes,1 Sebastiaan van Sandijk,8 Lars Halvorsen,9 Peter R ...
Raventós B, Fernández-Bertolín S, Aragón M, Voss EA, Blacketer C, Méndez-Boo L, Recalde M, Roel E, Pistillo A, Reyes C, van Sandijk S, Halvorsen L, Rijnbeek PR, Burn E, Duarte-Salles T   +14 more
doaj  

Common principal components model for symbolic data

Journal of the Japanese Society of Computational Statistics, 2010
This paper proposes a dimension reduction technique in the framework of symbolic data analysis (SDA). Recent advances in technology have increased the complexity of datasets, and today, their size is much larger than it was in the past decade. Most statistical methods do not have sufficient power to analyze these datasets.
Kotoe Katayama, Hiroyuki Minami, Masahiro Mizuta   +2 more
openaire   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Markov-Switching Common Dynamic Factor Model with Mixed-Frequency Data [PDF]

In this paper, we consider a coincident economic indicator model with regime-switching dynamics and with the time series observed at different frequencies, for instance, at monthly and quarterly frequencies.
Konstantin A. KHOLODILIN
core  

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

An assessment of the European Patient Summary for clinical research: a case study in cardiology

Frontiers in Medicine
IntroductionThe European Health Data Space (EHDS) initiative was launched to create a unified framework for health data exchange across Europe. Central to this initiative is the European Electronic Health Record Exchange Format, designed to achieve ...
Gokce Banu Laleci Erturkmen, Ali Anil Sinaci, Tuncay Namli, Machteld J. Boonstra, Machteld J. Boonstra, Machteld J. Boonstra, Karim Lekadir, Karim Lekadir, Polyxeni Gkontra, Catherine Chronaki, Rhonda Facile, Rebecca Baker, Rebecca Kush   +12 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source