Results 41 to 50 of about 17,485,358 (248)
The Time to Most Recent Common Ancestor Does Not (Usually) Approximate the Date of Divergence.
PLoS ONE, 2015 With the advent of more sophisticated models and increase in computational power, an ever-growing amount of information can be extracted from DNA sequence data.
James B Pettengill
doaj +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Establishing a comprehensive apheresis medicine program in a resource‐constrained setting presents significant structural, financial, and logistical challenges. Despite the growing clinical importance of apheresis services globally, published experience from sub‐Saharan Africa remains sparse.
Folasade Adelekan‐Popoola +4 more
wiley +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo +5 more
wiley +1 more source
Minimization of total absolute deviation for a common due date
, 2007 [[abstract]]This study addresses a non-preemptive single-machine scheduling problem with specific penalty parameters for each job in which all jobs have a common due date and zero ready time.
Wang, Jenhung;Lin, Pei-Chun +2 more
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Peptide drugs application in metabolic diseases and discovery strategies
Journal of Holistic Integrative Pharmacy, 2022 Peptides (or polypeptides) are generally defined as those molecules compounded with less than 100 amino acids linked by peptide bonds, and the relative molecular weight is less than 10 000 Da usually. To date, more than 7 000 naturally peptides have been
Bin TENG, Junfeng LI, Peigen REN
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Nasal obstruction as a drug side effect
Therapeutic Advances in Respiratory Disease, 2011 Nasal obstruction is a common symptom of various diseases, allergies, and structural deformities and a ‘stuffy nose’ is one of the most common reasons that patients seek a physician’s aid.
Cemal Cingi +2 more
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Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
MathematicsThis study evaluates the efficiency of a swarm intelligence algorithm called marriage in honey-bee optimization (MBO) in solving the single-machine weighted earliness/tardiness problem, a type of NP-hard combinatorial optimization problem. The goal is to
Pedro Palominos +3 more
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