Results 211 to 220 of about 61,983 (254)

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

Multiple outflows and delayed ejections revealed by early imaging of novae. [PDF]

Nat Astron
Aydi E, Monnier JD, Mérand A, Schaefer GH, Chomiuk L, Otulakowska-Hypka M, Fan JL, Li KL, Sokolovsky KV, Salinas R, Tucker M, Shappee B, Rudy R, Page KL, Kuin NPM, Buckley DAH, Craig P, Izzo L, Linford J, Metzger BD, Mukai K, Orio M, Shen KJ, Strader J, Sokoloski JL, Williams RE, Williams MN, Habtie GR, Kraus S, Anugu N, Bouquin JL, Chhabra S, Codron I, Gardner T, Gutierrez M, Ibrahim N, Lanthermann C, Setterholm BR, Ashall C, Hinkle JT, Jaeger T, Payne AV.   +41 more
europepmc   +1 more source

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation

Advanced Science, EarlyView.
Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu, Xue Yuan, Yan Zhou, Rui Yuan, Shaocheng Xie, Yong Chen, Peiyi Wang, Jianmei Gao, Qihai Gong   +8 more
wiley   +1 more source

Lifestyles of <i>Gypsy</i>-family transposons shape their regulatory mechanisms. [PDF]

Proc Natl Acad Sci U S A
Papameletiou AM, Nicholson BC, Bornelöv S, Hannon GJ.   +3 more
europepmc   +1 more source

A Multiscale Mechanistic Framework for Polydopamine Dyeing in Ultrablack Wool Textiles

Advanced Science, EarlyView.
Ultrablack photonic textiles are enabled through polydopamine (PDA) dyeing, which is governed by the interplay of PDA chemistry, wool surface topology and chemistry, and hierarchical fiber–yarn–fabric architecture. Fabric architecture emerges as a primary and previously underappreciated design lever for wide‐angle optical performance.
Hansadi Jayamaha, Kumar Siddharth, Kyuin Park, Mia Bressler, Larissa M. Shepherd   +4 more
wiley   +1 more source

Impaired Membrane Energetics Underlies Collateral Sensitivity to Amphenicols During Meropenem Resistance Evolution in <i>Escherichia coli</i>. [PDF]

Microorganisms
Li Y, Jiang Q, Zheng T, Sun R, Zhang H, Ren H, Fang L, Zhou Y, Sun J, Liao X.   +9 more
europepmc   +1 more source

SynNotch Receptors for Visualizing Immunoreceptor Force Transmission and Downstream Signaling In Vivo

Advanced Science, EarlyView.
A mechanically activated SynNotch reporter platform enables detection of force transmission through receptors as they mediate immune cell interactions. Targeting CD40 on B cells and TCR on T cells records force‐induced reporter activation across 2D coculture, 3D organoid, and implanted in mice, which also reveal force‐amplification of immune receptor ...
Menglan Li, Jintian Lyu, Kaitao Li, Ameya Dravid, Deepali Balasubramani, Amir H. K. Ashkezari, Hyun‐Kyu Choi, Gabriel A. Kwong, Ankur Singh, Cheng Zhu   +9 more
wiley   +1 more source

Molecular Characterisation of Orf Virus in Goats From Eastern Türkiye. [PDF]

Vet Med Sci
Özbek R, Ilgın M, Can-Şahna K.
europepmc   +1 more source

Mesoporous PU/PEDOT:PSS Electrodes Reveal Population‐Level Stochastic Bioelectrical Dynamics in Marine Diatoms

Advanced Science, EarlyView.
Mesoporous mixed ionic‐electronic PU/PEDOT: PSS electrodes enable label‐free detection of stochastic extracellular bioelectrical dynamics in living Phaeodactylum tricornutum. Living diatoms actively modulate interfacial ionic dynamics, establishing stochastic electrochemical noise as a sensitive probe of microbial bioelectrochemical activity and a new ...
David M. S. Silva, Felipe L. Bacellar, Raquel Amaral, Louis‐Josselin Lavier‐Aydat, Luísa Cortes, Kamal Asadi, Leïla Tirichine, Paulo R. F. Rocha   +7 more
wiley   +1 more source

Atmospheric Water Harvesting Through Polymer Hydrogel Sorbents: Materials Chemistry, Design Strategies, and Applications

Advanced Science, EarlyView.
Polymer‐based hydrogels have emerged as promising materials for atmospheric water harvesting (AWH) due to their high water affinity, tunable network structure, and excellent moisture adsorption‐desorption performance. Functional hydrogel systems enable efficient water capture and controlled release under low‐energy conditions, offering a sustainable ...
Swagata Datta, Sushmit Sen, Nilanjan Dey, Amrita Chatterjee, Ananya Sadhu, Sudipta Sarkar, Pradip K. Maji   +6 more
wiley   +1 more source