Results 91 to 100 of about 3,542,049 (321)

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Note on recent common coupled fixed point results in multiplicative metric spaces [PDF]

, 2018
Huaping Huang, Guantie Deng, Tatjana Došenović, Nawab Hussain   +3 more
openalex   +1 more source

Common Fixed Point Results for Compatible Mappings of Type (C)

, 2023
Mumtaz Ali, Muhammad Arshad
openalex   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Fixed Point and Common Fixed Point Theorems for Generalized Weak Contraction Mappings of Integral Type in Modular Spaces

International Journal of Mathematics and Mathematical Sciences, 2011
We prove new fixed point and common fixed point theorems for generalized weak contractive mappings of integral type in modular spaces. Our results extend and generalize the results of A. Razani and R. Moradi (2009) and M. Beygmohammadi and A.
Chirasak Mongkolkeha, Poom Kumam
doaj   +1 more source

Relation-theoretic coincidence and common fixed point results under (F,R)g $(F,\mathcal{R})_{g}$-contractions with an application

Fixed Point Theory and Applications, 2019
In this paper, we begin with some observations on F-contractions. Thereafter, we introduce the notion of (F,R)g $(F,\mathcal{R})_{g}$-contractions and utilize the same to prove some coincidence and common fixed point results in the setting of metric ...
Waleed M. Alfaqih, Mohammad Imdad, Rqeeb Gubran, Idrees A. Khan   +3 more
doaj   +1 more source

Common fixed point and common coupled fixed point theorems for weakly monotone mappings

Boletim da Sociedade Paranaense de Matemática
In this paper we have established two common fixed point theorems which are variants of the fixed point theorem of Boyd and Wong [On nonlinear contractions, Proc. Amer. Math. Soc. 20(1969), 458-464]. By applying the newly established fixed point theorems two common coupled fixed point theorems have been proved for a pair of weakly increasing mappings ...
E. Prajisha, P. Shaini
openaire   +3 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source