Results 131 to 140 of about 11,109,677 (306)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

New Fixed-Point and Common Fixed-Point Results in Finite-Dimensional Normed Pre-A∗ Vector Spaces

open access: yesInternational Journal of Mathematics and Mathematical Sciences
This paper establishes new fixed-point and common fixed-point theorems for continuous and asymptotically regular self-maps defined on finite-dimensional normed pre-A∗ vector spaces over σ-complete pre-A∗-algebras.
Kidanemariam Birhane Gebremedhin   +2 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

A new fixed point approximation method for solving third-order BVPs based on Green's function [PDF]

open access: yes
This study presents an interesting method based on Picard-Ishikwa fixed point iterative method to solve nonlinear third-order boundary value problems.
Udo, M. O.   +3 more
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

Mönch sets and fixed point theorems for multimaps in locally convex topological vector spaces

open access: yes, 2017
We present a variety of fixed point theorems for multimaps having weakly closed graph. We state in turn Sadovskii, Monch and Daher type theorems which improve recent results in the literature.
Rubbioni, Paola   +2 more
core   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

open access: yesFEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui   +4 more
wiley   +1 more source

Fixed Point Results for Admissible <i>z</I>-contractions

open access: yes, 2018
KARAPINAR, ERDAL/0000-0002-6798-3254; Cvetkovic, Marija/0000-0003-0691-3428; Cvetkovic, Marko/0000-0003-4425-8575In this paper, we present some fixed point results in the setting of a complete metric spaces by defining a new contractive condition via ...
Karapinar, Erdal   +2 more
core   +1 more source

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