FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source
A general Richards family growth curve fit in European livestock for use in physiologically-based toxicokinetic modelling. [PDF]
BMC Vet ResInauen D +3 more
europepmc +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Measuring early word exposure in infants: A brief parent-report survey captures individual language input and predicts vocabulary outcomes. [PDF]
Dev PsycholDong Y +3 more
europepmc +1 more source
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
Environmental context shapes sex-specific costs of reproduction in a dioecious plant. [PDF]
Ann BotGibson MT, Emery RJN, Dorken ME.
europepmc +1 more source
Development of human monoclonal antibodies against TARM1 by yeast display
FEBS Open Bio, EarlyView.Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe +5 more
wiley +1 more source
Intermittent Two-Point Dynamics at the Transition to Chaos for Random Circle Endomorphisms. [PDF]
Commun Math PhysGoverse VPH, Homburg AJ, Lamb JSW.
europepmc +1 more source
Bayesian Random-Effects Meta-Analysis of Aggregate Data on Clinical Events. [PDF]
Stat MedRöver C, Wu Q, Loos A, Friede T.
europepmc +1 more source
Flows of Conformally Coclosed G 2 -Structures with Dilaton. [PDF]
J Geom AnalKarigiannis S, Picard S, Suan C.
europepmc +1 more source