Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
From “common goods” to the “common good of humanity”
Historia Actual On-Line, 2011 La presente crisis sistémica del capitalismo y sus distintas dimensiones en los ámbitos de la economía, la energía, el alimento, los ecosistemas, los valores... requieren un nuevo análisis.
François Houtart
doaj
Public Works Programmes and Cooperation for the Common Good: Evidence from Malawi. [PDF]
Eur J Dev Res, 2022 Beierl S, Dodlova M.
europepmc +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
The COVID-19 Pandemic: Reshaping Public Health Policy Response Envisioning Health as a Common Good. [PDF]
Int J Environ Res Public Health, 2022 Vito D, Lauriola P, D'Apice C.
europepmc +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
NAVIGATING COMMON GOOD AS THE FRAMEWORK OF PROMOTING RELIGIOUS MODERATION EDUCATION IN INDONESIA
Jurnal TatsqifAs a nation with highly multicultural societies, Indonesia comprises various ethnic groups, customs, cultures, and religions. This often triggers societal conflicts between tribes, cultures, and beliefs.
Sopiyan Iqbal +2 more
doaj +1 more source
COVID-19 vaccination program: the Catholic Church's all-time support to the government when it is for the common good. [PDF]
J Public Health (Oxf), 2022 Lacsa JEM.
europepmc +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source