Results 51 to 60 of about 1,455,547 (299)
Une introduction aux communs de la connaissance
Tic & Société, 2018 We propose an introduction to the knowledge commons based on an attempt to define the commons themselves, and then evaluate how they are related to the intangible fields of knowledge and the digital. It seems difficult to settle on a canonical definition
Hervé LE CROSNIER
doaj +1 more source
Personal Privacy and Common Goods: A Framework for Balancing Under the National Health Information Privacy Rule [PDF]
, 2002 In this Article, we discuss how these principles for balancing apply in a number of important contexts where individually identifiable health data are shared. In Part I, we analyze the modern view favoring autonomy and privacy.
Gostin, Lawrence O. +1 more
core +2 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Il ruolo delle pratiche di riuso e condivisione degli spazi aperti nei processi di commoning urbano
Ri-vista: Ricerche per la Progettazione del Paesaggio, 2016 The role of the practices of reuse and sharing of open spaces in the processes of urban commoning. This essay examines the perspectives that the practices of reuse and sharing of open spaces, which over time have lost their original function (the so ...
Giuseppe Caridi
doaj +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Patrimonio territoriale e coralità produttiva: nuove frontiere per i sistemi economici locali
Scienze del Territorio, 2018 The territorialist alternative to a development model menacing to destroy life contexts is based on experimenting and networking new forms of ‘bottom-up’ local development, based on the enhancement of territorial heritage as common good.
Giuseppe Dematteis, Alberto Magnaghi
doaj +1 more source
Money as a Tool for Collective Action
Partecipazione e Conflitto, 2020 Complementary currencies are usually seen as a by-product of collective movements for social change or as an institutional tool for local development: they are an outcome of collective action, not the origin of collective mobilisation. Empirical research
Giacomo Bazzani
doaj +1 more source
Private Provision of Public Goods under Delegated Common Agency [PDF]
This paper considers a delegated common agent who produces a public good with private information regarding his cost. We show that truthful strategies are not optimal for principals, and that the agent enjoys some rent in equilibrium.
Tsung-Sheng Tsai
core
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source