Results 61 to 70 of about 99,860 (311)
Patrimonio territoriale e coralità produttiva: nuove frontiere per i sistemi economici locali
Scienze del Territorio, 2018 The territorialist alternative to a development model menacing to destroy life contexts is based on experimenting and networking new forms of ‘bottom-up’ local development, based on the enhancement of territorial heritage as common good.
Giuseppe Dematteis, Alberto Magnaghi
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Health Systems & Reform, 2019 Common goods such as air, water, climate, and other resources shared by all humanity are under increasing pressure from growing population and advancing globalization of the world economy. Safeguarding these resources is generally considered a government
Jesse B. Bump +2 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Between the Common Good and Good Living: Long-Distance Affinities
Íconos, 2014 The current work seeks to identify affinities and dissonance between the good living (buen vivir) to which legal and political priority was given in recent constitutional reforms in Ecuador and Bolivia and the common good (bien común), which in a ...
Francesca Belotti
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Private Provision of Public Goods under Delegated Common Agency [PDF]
This paper considers a delegated common agent who produces a public good with private information regarding his cost. We show that truthful strategies are not optimal for principals, and that the agent enjoys some rent in equilibrium.
Tsung-Sheng Tsai
core
Reconsiderando las tecnologías sociales como bienes comunes [PDF]
Íconos, 2010 En este artículo se describen las relaciones que se plantean entre las regulaciones sobre bienes materiales e intelectuales y las “tecnologías sociales”.
Ariel Vercelli
doaj
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source