Results 81 to 90 of about 11,793,615 (297)
A Monad-Based Formalization of Common Knowledge
We present here a novel approach to the analysis of common knowledge based on Category Theory. We formalize knowledge hierarchies as presheaves over a category of agent sequences. The category of these presheaves constitutes a topos.
Fernando Tohmé +2 more
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
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openaire +2 more sources
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Communication Can Destroy Common Learning [PDF]
We show by example that communication can generate a failure of common knowledge acquisition. In the absence of communication, agents acquire approximate common knowledge of some parameter, but with communication they do not.Common knowledge ...
Jakub Steiner, Colin Stewart
core +2 more sources
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
For common knowledge to arise in dynamic settings, all players must simultaneously come to know it has arisen. Consequently, common knowledge cannot arise in many realistic settings with timing frictions. This counterintuitive observation of Halpern and Moses (1990) was discussed by Arrow et al. (1987) and Aumann (1989), was called a paradox by Morris (
Yannai A. Gonczarowski, Yoram Moses
openaire +2 more sources
Communication, Timing, and Common Learning [PDF]
We study the effect of stochastically delayed communication on common knowledge acquisition (common learning). If messages do not report dispatch times, communication prevents common learning under general conditions even if common knowledge is acquired ...
Jakub Steiner, Colin Stewart
core +2 more sources

