Results 211 to 220 of about 3,195 (236)

Trust Matters: Examining the Dynamics of Management's Trust in Employee Representation

British Journal of Industrial Relations, EarlyView.
ABSTRACT While trust's relevance in employment relations has been recognised by scholars, empirical studies on management's trust in employee representation are notably scarce. The paper addresses this gap, contributing to a more comprehensive understanding of the dynamics that shape effective dialogue in the employment relationship.
Argyro Avgoustaki, Kabiru Oyetunde, Rea Prouska   +2 more
wiley   +1 more source

Effects of FGF4/HIF-1α axis-mediated neuronal glycolysis on neuropathic pain. [PDF]

J Headache Pain
Wu Q, Chen Y, Yao X, Ren S, Xie H, Li S, Ying X, Wang X.   +7 more
europepmc   +1 more source

New biosensors and transgenic mice for multiplex cGMP imaging

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a versatile second messenger that is important for human (patho‐)physiology and pharmacotherapy. Live‐cell imaging of cGMP with biosensors allows to elucidate its spatiotemporal dynamics in real time under close‐to‐native conditions. However, to monitor two separate cGMP pools or cGMP/cAMP
Markus Wolters, Martin Thunemann, Barbara Birk, Susanne Feil, Viacheslav O. Nikolaev, Moritz Lehners, Robert Feil   +6 more
wiley   +1 more source

Increasing Oligonucleotide Sequencing Information and Throughput with Ion Mobility Spectrometry-Mass Spectrometry. [PDF]

J Am Soc Mass Spectrom
Ryan JP, Slysz GW, Rye P, Stow SM, Dodds JN, Sausen J, Baker ES.   +6 more
europepmc   +1 more source

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

Human T-Lymphotropic Virus Type 1-Associated Myelopathy With Autoimmune Cholangiopathy: An Unusual Immune Conundrum in a Young Patient. [PDF]

Case Rep Infect Dis
Saad A, Jadoon Y, Sabir R.
europepmc   +1 more source

Hypericin Suppresses Liver Cancer Through Autophagic Degradation of AKT and Eliciting Antitumor Immune Response

Cancer Science, EarlyView.
Hypericin induces autophagic AKT degradation by promoting AKT‐HSPA5 interaction in an S473 phosphorylation‐dependent manner, suppressing HCC growth. It enhances CD8+ T cell‐mediated antitumor immunity and synergizes with anti‐PD‐L1 therapy, showing favorable safety for HCC treatment. ABSTRACT Hepatocellular carcinoma (HCC) is the most prevalent primary
Sien Ma, Qianqian Xu, Mengjuan Zhu, Xianming Ge, Jian Xu, Yan Pan, Mengli Wang, Yuting Zhu, Aoxuan Xu, Hanmeng Liu, GuangHai Xiang, Weipeng Gong, Bao Zhao   +12 more
wiley   +1 more source

An aerosolized dual-action autotaxin inhibitor-PPARγ agonist for the treatment of pulmonary fibrosis. [PDF]

Cell Rep Med
Matralis AN, Stylianaki EA, Ladopoulou EM, Kanellopoulou P, Smyrniotis S, Magkrioti C, Papavasileiou KD, Willems S, Rincon Pabon JP, Nastos D, Galaras A, Moro C, Dedos SG, Kaffe E, Hatzis P, Osman-Ponchet H, Merk D, Politis A, Afantitis A, Tseti I, Antoniou KM, Wells AU, Aidinis V.   +22 more
europepmc   +1 more source

Proteomics- and BRET- screens identify SPRY2 as a Ras effector that impacts its membrane organization. [PDF]

iScience
Pavic K, Hood FE, Duval CJ, Manoharan GB, Laurini C, Siddiqui FA, Mo SPL, Prior IA, Abankwa DK.   +8 more
europepmc   +1 more source