Results 221 to 230 of about 3,195 (236)

Lactate‐Primed NETosis Modulates Hepatic Regeneration During Acute Liver Failure via the TLR9/KLF15/AJUBA Axis

Cell Proliferation, EarlyView.
This study elucidates a novel Kupffer cell‐neutrophil‐hepatocyte axis that drives metabolic‐immune crosstalk during acute liver failure. Specifically, lactate‐primed NETs release links metabolic reprogramming to NETosis‐induced regenerative failure in hepatocytes via the TLR9/KLF15/AJUBA axis.
Jin Guo, Xiaoya Zhang, Danmei Zhang, Chunxia Shi, Luwen Wang, Zuojiong Gong   +5 more
wiley   +1 more source

Computational Investigation of Novel pUL56 Ligands Using Docking and Molecular Dynamics with Preliminary Cytotoxicity Evaluation: An Early-Stage Study. [PDF]

Molecules
Feoktistova V, Afolabi SO, Klabukov AM, Shtro AA, Kolobov AV, Baichurin RI, Skorb EV, Shityakov S.   +7 more
europepmc   +1 more source

PLIN5 Protects Against Ang II‐Induced Podocyte Lipotoxicity by Interacting With FKBP8 and Preserving Lipid Droplet–Mitochondria Contact

Cell Proliferation, EarlyView.
PLIN5‐FKBP8 tethers lipid droplets to mitochondria to counteract Ang II‐induced lipotoxicity. ABSTRACT Chronic kidney disease (CKD) remains a major global health challenge. Angiotensin II (Ang II)‐induced lipotoxicity is an important contributor to podocyte injury.
Ping Wang, Wenjie Chen, Jingjing Ke, Hongtu Hu, Zhuan Peng, Yue Qi, Guohua Ding, Jijia Hu   +7 more
wiley   +1 more source

Proton-selective conductance and gating of the lysosomal cation channel TMEM175. [PDF]

Proc Natl Acad Sci U S A
Schulze T, Sprave T, Groebe C, Hendrik Krumbach J, Behringer M, Bazzone A, Zerlotti R, Fertig N, Althaus M, Hamacher K, Thiel G, Grimm C, Rauh O.   +12 more
europepmc   +1 more source

Clinical and genetic characterization of intellectual disability

Developmental Medicine &Child Neurology, EarlyView.
This study examines the etiological factors and comorbidities in a large cohort of Finnish patients with intellectual disability. Genetic causes—including chromosomal abnormalities and pathogenic gene variants—were more frequently identified in individuals with moderate to profound intellectual disability.
Aarni Venetvaara, Minna Kraatari‐Tiri, Jussi‐Pekka Tolonen, Marko Merikukka, IDGEN Study Group, Hannaleena Kokkonen, Teija Paakkola, Susanna Varis, Antti Dahl, Jarmo Körkkö, Jonna Komulainen‐Ebrahim, Jukka Moilanen, Johanna Uusimaa, Outi Kuismin, Elisa Rahikkala   +14 more
wiley   +1 more source

Intrinsic resistance to RAS inhibitors is driven by dysregulation of KRAS degradation. [PDF]

Nat Commun
Ivanisevic T, Ma Y, Van Boxel E, Magits W, Lechat B, Koçberber Z, Willnow P, Fendt SM, Velde GV, Sewduth R, Sablina AA.   +10 more
europepmc   +1 more source

The cerebral palsy directed acyclic graph: A structural causal model of aetiology

Developmental Medicine &Child Neurology, EarlyView.
The first international cerebral palsy directed acyclic graph (CP‐DAG) maps over 100 nodes and 370 links across biological, clinical, and social domains, offering a unified causal framework to guide research and identify knowledge gaps. Abstract Aim To describe the development of the initial version of the cerebral palsy (CP) directed acyclic graph ...
Shona Goldsmith, Sarah McIntyre, Nadia Badawi, Bernard Dan, Steven Day, Kate Himmelmann, Sandra Julsen Hollung, Bo Jacobsson, Gija Rackauskaite, Robert J. Reynolds   +9 more
wiley   +1 more source

Pharmacological administration of FGF21 reverses obesity through a parabrachial-projecting neuron population in the hindbrain. [PDF]

Cell Rep
Lin Y, Claflin KE, Aklan I, Morgan DA, Sullivan AI, Rudolph MC, Rahmouni K, Potthoff MJ.   +7 more
europepmc   +1 more source

Resolving oligomeric states of photoactivatable proteins in living cells via photon counting histogram analysis. [PDF]

iScience
Camp T, Li Z, Li Y, Oh TJ, Zhang K.
europepmc   +1 more source

Bioorthogonal Click Chemistry for Antibody-Free Profiling of Acetylation, Propionylation, and Butyrylation in <i>Pseudomonas aeruginosa</i> and Methicillin-Resistant <i>Staphylococcus aureus</i>. [PDF]

ACS Infect Dis
Monacchio HN, Shah RS, Montes CF, Wang GZ, Walley JW, VanDrisse CM.   +5 more
europepmc   +1 more source