Results 31 to 40 of about 406,513 (211)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

LODE: Linking Digital Humanities Content to the Web of Data

open access: yes, 2014
Numerous digital humanities projects maintain their data collections in the form of text, images, and metadata. While data may be stored in many formats, from plain text to XML to relational databases, the use of the resource description framework (RDF ...
Allen, Colin   +5 more
core   +1 more source

Condorcet Domains, Median Graphs and the Single Crossing Property [PDF]

open access: yes, 2016
Condorcet domains are sets of linear orders with the property that, whenever the preferences of all voters belong to this set, the majority relation has no cycles.
Puppe, Clemens, Slinko, Arkadii
core   +3 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Coherent random permutations with record statistics

open access: yes, 2006
Random permutations with distribution conditionally uniform given the set of record values can be generated in a unified way, coherently for all values of $n$.
Gnedin, Alexander
core   +3 more sources

Economic Impacts of Noxious Facilities: Incorporating the Effects of Risk Aversion [PDF]

open access: yes, 1993
The author suggests an integrative approach for projecting economic impacts of facilities that elicit public Risk aversion. She incorporates both economic stimulus effects and perception-based effects of facilities on the host area economy.
Nieves, Leslie A.
core   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Improving Pairwise Ranking for Multi-label Image Classification

open access: yes, 2017
Learning to rank has recently emerged as an attractive technique to train deep convolutional neural networks for various computer vision tasks. Pairwise ranking, in particular, has been successful in multi-label image classification, achieving state-of ...
Li, Yuncheng, Luo, Jiebo, Song, Yale
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

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