Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Diagnosing watersheds in India: Integrating power and politics in the analysis of commons governance
Water Alternatives, 2021 The experience of watershed development and management in countries of the Global South highlights significant challenges to governance. Establishing the overlap between watershed and commons, this paper identifies some of the most critical challenges ...
Shashank Deora
doaj
Media education and educational commons for youth civic engagement. A case study from the Horizon 2020 project SMOOTH. [PDF]
Front Sociol, 2022 Cappello G, Siino M.
europepmc +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
(Un)common spaces of becoming in common: a feminist exploration of designing as/for commoning [PDF]
This feminist practice-based research has a two-fold concern: firstly, to investigate the emancipatory potential of ‘(un)common spaces of becoming in common’ in the neoliberal city to foster civic agency, solidarity and care in our everyday lives in ...
Moebus, Katharina
core
An instituting-organisational framework for the interpretation of urban commoning. : Lessons from a neighbourhood park [PDF]
Drawing on critical scholarship on commoning processes, this article aims to contribute to the debate by reflecting on an argumentative case that took place in a neighbourhood public park on the northern outskirts of the city of Catania in Italy.
Pappalardo, Giusy, Saija, Laura
core +1 more source
“Lifting the Roof” With Democracy-as-Becoming
Journal of Awareness-Based Systems ChangeContemporary societies face interrelated crises that strain democratic institutions, social cohesion, and ecological conditions. This article approaches governance as a relational, processual practice that can be reconfigured in and through aesthetic ...
Lea Spahn +5 more
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
(En) coding care into digital urbanism: Vignettes of collective practices
Digital Geography and SocietyThe tech-entrepreneurial model behind the computation of urban processes is (re) producing what has already been identified as a technocratic, solutionist, and commodifying model of urban planning.
Niloufar Vadiati +2 more
doaj +1 more source
Joining with the Conversation: Research as a Sustainable Practice in the Sport Sciences. [PDF]
Sports Med Open, 2022 Woods CT, Araújo D, Davids K.
europepmc +1 more source