Results 171 to 180 of about 698 (301)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Seeds of change : exploring the potential of a “commoning education” through the social organisation of pedagogical gardens [PDF]

This thesis brings together perspectives from commoning literature, a critique of neoliberal capitalism, and alternative education exemplified through pedagogical gardens.
Nordstrand, Sofia
core  

Coding the future: digital technologists and the constitution of the next system. [PDF]

Front Sociol
Deepak D, Manski B.
europepmc   +1 more source

Managing the curb - Public space and use of curbside cafes during the Coronavirus pandemic. [PDF]

Cities, 2023
Mandhan S, Gregg K.
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

La symbiose féministe, comprendre les initiatives féministes de commoning par l’approche symbiotique

Feminist initiatives are organizing to generate social transformations, weaving together various feminist cause spaces. These initiatives resemble multi-actor commoning processes.
Lecomte, Louise
core  

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

The feminist symbiosis, understanding feminist commoning initiatives through the symbiotic approach

Les initiatives féministes s’organisent pour générer des transformations sociales, maillant différents espaces de cause féministes. Ces initiatives s’apparentent à des processus de commoning multi-acteurs.
Lecomte, Louise
core  

Addressing durability in collaborative organising: Event atmospheres and polyrhythmic affectivity. [PDF]

Hum Relat
Resch B, Rozas D.
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source