Results 61 to 70 of about 325,417 (262)
UNRAVELING THE ARCHITECTURE OF THE DORSAL RAPHE SYNAPTIC NEUROPIL USING HIGH-RESOLUTION NEUROANATOMY
Frontiers in Neural Circuits, 2014 The dorsal raphe nucleus (DRN), representing the main source of brain’s serotonin, is implicated in the pathophysiology and therapeutics of several mental disorders that can be debilitating and life-long including depression, anxiety and autism.
Mariano eSoiza-Reilly +3 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
‘Common things are common’ [PDF]
QJM: An International Journal of Medicine, 2017 M Razmi T, R V Nampoothiri, S Dogra
openaire +2 more sources
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Data-driven tools for optimizing urban tree planting strategies
City and Environment InteractionsIn this study, we propose a universally applicable, two-level approach aimed at optimizing both tree planting locations and species selection, integrating the model into an intuitive Web Application.
Luca Maccacaro +4 more
doaj +1 more source
Concern noted: a descriptive study of editorial expressions of concern in PubMed and PubMed Central
Research Integrity and Peer Review, 2017 Background An editorial expression of concern (EEoC) is issued by editors or publishers to draw attention to potential problems in a publication, without itself constituting a retraction or correction.
Melissa Vaught +2 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
From Targets to Action: Rolling up our Sleeves after Paris
Global Challenges, 2017 At the United Nations Climate Change Conference in Paris in 2015 ambitious targets for responding to the threat of climate change have been set: limiting global temperature increase to “well below 2 °C […] and to pursue efforts to limit the temperature ...
Brigitte Knopf +5 more
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
BMJ, 2004 Do patients with venous ulcers get pain A: most of the time? B: commonly? C: often? D: rarely? We all use imprecise terms in our writing, but such terms cause confusion when they are used in examination questions. We have all experienced sitting an examination and wondering what …
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