Results 51 to 60 of about 198,227 (313)

Isolation of a Novel Fusogenic Orthoreovirus from Eucampsipoda africana Bat Flies in South Africa

Viruses, 2016
We report on the isolation of a novel fusogenic orthoreovirus from bat flies (Eucampsipoda africana) associated with Egyptian fruit bats (Rousettus aegyptiacus) collected in South Africa.
Petrus Jansen van Vuren, Michael Wiley, Gustavo Palacios, Nadia Storm, Stewart McCulloch, Wanda Markotter, Monica Birkhead, Alan Kemp, Janusz T. Paweska   +8 more
doaj   +1 more source

First confirmed case of infant botulism in Africa, caused by a dual-toxin-producing Clostridium botulinum strain

International Journal of Infectious Diseases, 2021
Botulism, a rare life-threatening toxemia, is probably underdiagnosed in all of its forms in Africa. This study reports the first laboratory-supported case of infant botulism on the African continent.
Marné N. Vosloo, Christoffel J. Opperman, Hermanus D.W. Geyer, Grace M. Setshedi, Mushal Allam, Stanford Kwenda, Arshad Ismail, Zamantungwa T.H. Khumalo, Adrian J. Brink, John A. Frean, Jennifer Rossouw   +10 more
doaj   +1 more source

The impact of temperature on insecticide toxicity against the malaria vectors Anopheles arabiensis and Anopheles funestus

Malaria Journal, 2018
Background It is anticipated that malaria elimination efforts in Africa will be hampered by increasing resistance to the limited arsenal of insecticides approved for use in public health.
Katey D. Glunt, Shüné V. Oliver, Richard H. Hunt, Krijn P. Paaijmans   +3 more
doaj   +1 more source

Regional Initiatives in Support of Surveillance in East Africa: The East Africa Integrated Disease Surveillance Network (EAIDSNet) Experience. [PDF]

, 2013
The East African Integrated Disease Surveillance Network (EAIDSNet) was formed in response to a growing frequency of cross-border malaria outbreaks in the 1990s and a growing recognition that fragmented disease interventions, coupled with weak laboratory
Bond KC, Gresham L, James Kariuki, Leonard E.G Mboera, Maurice Ope, Mayala BK, Mboera LEG, Miriam Schneidman, Mwihaki Kimura, Olago D, Ramana N.V Gandham, Shikanga O, Stanley Sonoiya, WHO, WHO   +14 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Tick bite risk factors and prevention measures in an area with emerging Powassan virus disease

Public Health Challenges, 2023
Background In the United States (U.S.), Powassan virus is primarily transmitted to humans by the black‐legged tick (Ixodes scapularis). Rarely, infections can present as severe neuroinvasive disease.
Nicolette Wilson, Grace M. Vahey, Emily McDonald, Kelly Fitzpatrick, Jennifer Lehman, Sandhya Clark, Kristine Lindell, Daniel M. Pastula, Stephen Perez, Heather Rhodes, Carolyn V. Gould, J. Erin Staples, Stacey W. Martin, Kim Cervantes   +13 more
doaj   +1 more source

Malaria risk and receptivity: Continuing development of insecticide resistance in the major malaria vector Anopheles arabiensis in northern KwaZulu-Natal, South Africa

South African Journal of Science, 2022
Malaria incidence in South Africa is highest in the three endemic provinces: KwaZulu-Natal, Mpumalanga and Limpopo. The contribution to malaria transmission by several mosquito species, variation in their resting behaviours and low levels of insecticide
Givemore Munhenga, Shüné V. Oliver, Leanne N. Lobb, Theresa T. Mazarire, Windy Sekgele, Thabo Mashatola, Nondumiso Mabaso, Dumsani M. Dlamini, Malibongwe Zulu, Fortunate Moletsane, Blaženka D. Letinić, Jacek Zawada, Ashley Burke, Avhatakali Matamba, Basil D. Brooke   +14 more
doaj   +1 more source

Modernising epidemic science: enabling patient-centred research during epidemics [PDF]

, 2016
Background: Emerging and epidemic infectious disease outbreaks are a significant public health problem and global health security threat. As an outbreak begins, epidemiological investigations and traditional public health responses are generally mounted ...
Horby, Peter W., Rojek, Amanda M.
core   +3 more sources