Results 61 to 70 of about 198,227 (313)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Fetal ultrasound measurements and associations with postnatal outcomes in infancy and childhood : a systematic review of an emerging literature [PDF]

, 2014
Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.Peer ...
Alkandari, Farah, Aucott, Lorna, Devereux, Graham, Ellahi, Awaiss, Turner, Steve   +4 more
core   +1 more source

Assessment of the non-communicable diseases kit for humanitarian emergencies in Yemen and Libya

BMJ Global Health, 2022
Emergency health kits are a vital way of providing essential medicines and supplies to health clinics during humanitarian crises. The WHO non-communicable diseases (NDCs) kit was developed 5 years ago, recognising the increasing challenge of providing continuity of care and secondary prevention of NCDs and exacerbations, in such settings.
Lilian Kiapi, Ahmad Hecham Alani, Iman Ahmed, Gemma Lyons, Grace McLain, Laura Miller, Bhavika Darji, Isaac Waweru, Mauricio Aragno, Kelly Kisarach, Mekuanint Zeleke, Nabeel Nagi, Vageesh Jain, Slim Slama   +13 more
openaire   +3 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Free-living amoebae infections in humans in South Africa, 1996-2023

International Journal of Infectious Diseases
Introduction: Free-living amoebae (FLA) exist independently in various environments such as soil and water and do not rely on human or animal hosts for survival.
Dr Shareen Boughan, Mrs Bhavani Moodley, Prof John Frean, Dr Charlotte Sriruttan-Nel   +3 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Rapid risk assessment for communicable diseases in humanitarian emergencies: validation of a rapid risk assessment tool for communicable disease risk in humanitarian emergencies

Global Biosecurity, 2019
Background: Communicable diseases pose a significant risk in humanitarian emergencies. This paper reports on the development and validation of a rapid risk assessment tool for communicable diseases in humanitarian emergencies. Methods: We developed a tool assessing the 20 most critical risk factors for disease outbreaks in humanitarian emergencies ...
Hammer, Charlotte, Brainard, Julii, Hunter, Paul   +2 more
openaire   +6 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Attempted Transmission of Marburg Virus by Bat-Associated Fleas Thaumapsylla breviceps breviceps (Ischnopsyllidae: Thaumapsyllinae) to the Egyptian Rousette Bat (Rousettus aegyptiacus)

Viruses
Egyptian rousette bats (ERBs) are implicated as reservoir hosts for Marburg virus (MARV), but natural mechanisms involved in maintenance of MARV in ERB populations remain undefined.
Janusz T. Pawęska, Nadia Storm, Petrus Jansen van Vuren, Wanda Markotter, Alan Kemp   +4 more
doaj   +1 more source

Analysis of the Cell Type-Dependence on the Arenavirus Z-Mediated Virus-Like Particle Production

Frontiers in Microbiology, 2020
Several arenaviruses are highly pathogenic to humans, causing hemorrhagic fever. Discovery of anti-arenavirus drug candidates is urgently needed, although the molecular basis of the host- and organ-specific pathogenicity remains to be fully elucidated ...
Patrick I. Mpingabo, Patrick I. Mpingabo, Shuzo Urata, Shuzo Urata, Jiro Yasuda, Jiro Yasuda, Jiro Yasuda   +6 more
doaj   +1 more source