Results 61 to 70 of about 194,149 (294)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Free-living amoebae infections in humans in South Africa, 1996-2023

International Journal of Infectious Diseases
Introduction: Free-living amoebae (FLA) exist independently in various environments such as soil and water and do not rely on human or animal hosts for survival.
Dr Shareen Boughan, Mrs Bhavani Moodley, Prof John Frean, Dr Charlotte Sriruttan-Nel   +3 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Regional Initiatives in Support of Surveillance in East Africa: The East Africa Integrated Disease Surveillance Network (EAIDSNet) Experience. [PDF]

, 2013
The East African Integrated Disease Surveillance Network (EAIDSNet) was formed in response to a growing frequency of cross-border malaria outbreaks in the 1990s and a growing recognition that fragmented disease interventions, coupled with weak laboratory
Bond KC, Gresham L, James Kariuki, Leonard E.G Mboera, Maurice Ope, Mayala BK, Mboera LEG, Miriam Schneidman, Mwihaki Kimura, Olago D, Ramana N.V Gandham, Shikanga O, Stanley Sonoiya, WHO, WHO   +14 more
core   +1 more source

Rapid risk assessment for communicable diseases in humanitarian emergencies: validation of a rapid risk assessment tool for communicable disease risk in humanitarian emergencies

Global Biosecurity, 2019
Background: Communicable diseases pose a significant risk in humanitarian emergencies. This paper reports on the development and validation of a rapid risk assessment tool for communicable diseases in humanitarian emergencies. Methods: We developed a tool assessing the 20 most critical risk factors for disease outbreaks in humanitarian emergencies ...
Hammer, Charlotte, Brainard, Julii, Hunter, Paul   +2 more
openaire   +6 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Attempted Transmission of Marburg Virus by Bat-Associated Fleas Thaumapsylla breviceps breviceps (Ischnopsyllidae: Thaumapsyllinae) to the Egyptian Rousette Bat (Rousettus aegyptiacus)

Viruses
Egyptian rousette bats (ERBs) are implicated as reservoir hosts for Marburg virus (MARV), but natural mechanisms involved in maintenance of MARV in ERB populations remain undefined.
Janusz T. Pawęska, Nadia Storm, Petrus Jansen van Vuren, Wanda Markotter, Alan Kemp   +4 more
doaj   +1 more source

Analysis of the Cell Type-Dependence on the Arenavirus Z-Mediated Virus-Like Particle Production

Frontiers in Microbiology, 2020
Several arenaviruses are highly pathogenic to humans, causing hemorrhagic fever. Discovery of anti-arenavirus drug candidates is urgently needed, although the molecular basis of the host- and organ-specific pathogenicity remains to be fully elucidated ...
Patrick I. Mpingabo, Patrick I. Mpingabo, Shuzo Urata, Shuzo Urata, Jiro Yasuda, Jiro Yasuda, Jiro Yasuda   +6 more
doaj   +1 more source

Acceptability of 4-poster deer treatment devices for community-wide tick control among residents of high Lyme disease incidence counties in Connecticut and New York, USA

Ticks and Tick-Borne Diseases, 2023
The 4-Poster Tick Control Deer Feeder (4-poster) device applies acaricide to white-tailed deer (Odocoileus virginianus) and can reduce populations of the blacklegged tick (Ixodes scapularis), which transmits the agents of Lyme disease, anaplasmosis ...
Courtney C. Nawrocki, Nicholas Piedmonte, Sara A. Niesobecki, Adam Rowe, AmberJean P. Hansen, Alison Kaufman, Erik Foster, James I. Meek, Linda Niccolai, Jennifer White, Bryon Backenson, Lars Eisen, Sarah A. Hook, Neeta P. Connally, Victoria L. Hornbostel, Alison F. Hinckley   +15 more
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source