Results 71 to 80 of about 2,291,416 (288)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Practical cryptographic strategies in the post-quantum era

, 2018
We review new frontiers in information security technologies in communications and distributed storage technologies with the use of classical, quantum, hybrid classical-quantum, and post-quantum cryptography.
Fedorov, A. K., Kabanov, I. S., Kurochkin, Y. V., Yunusov, R. R.   +3 more
core   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Information and communication technologies for the poor: [PDF]

This brief is based on Information and Communication Technologies for Development and Poverty Reduction: The Potential of Telecommunications, ed. Maximo Torero and Joachim von Braun (Johns Hopkins University Press and IFPRI, 2006) "The variety of views ...
Torero, Maximo, von Braun, Joachim
core  

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

An integrated approach to forecasting software system quality using bayesian correction, multi-criteria optimization, and meta-learning

Радіоелектронні і комп'ютерні системи
The aim of this study is to improve modern methods for forecasting the quantitative characteristics of software system quality to enhance reliability, efficiency, and adaptability in dynamic IT environments.
Anton Shantyr, Olha Zinchenko, Kamila Storchak, Viktor Vyshnivskyi, Olga Morozova   +4 more
doaj   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Rethinking young children creating and communicating : research briefing 3 for digital childhoods [PDF]

, 2011
This briefing paper specifically considers children’s early communicative and creative experiences with digital technologies, addressing the following questions: »» What are children learning about the roles digital technologies play in supporting ...
Mcpake, Joanna
core  

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Business Intelligence System via Group Decision Making

Cybernetics and Information Technologies, 2016
In the paper a business intelligence tool based on group decision making is proposed. The group decision making uses a combinatorial optimization modeling technique. It takes into account weighted coefficients for evaluation criteria assigned by decision
Borissova Daniela, Mustakerov Ivan, Korsemov Dilian   +2 more
doaj   +1 more source