Results 91 to 100 of about 474,222 (313)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Professionally-Oriented Communicative Language Teaching Approach by the Design of a Computer Assisted ESP Course: Analysis of Results [PDF]

, 2000
Professionally-Oriented Communicative Language Teaching is an effective approach widely recognized among scientists and teachers which involves learners in authentic environment and communication and helps develop communicative competence of non-native ...
Anastassiya A. Chernaya, Canale, Chernova, Ekaterina A. Golovacheva, Elvira Ya. Sokolova, Robert, Summaira Sarfraz   +6 more
core   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

TEACHERS' PERSPECTIVE ON THE IMPLEMENTATION OF COMMUNICATIVE APPROACH IN INDONESIAN CLASSROOMS

IJEE (Indonesian Journal of English Education), 2018
Communicative Approach (CA) is probably the most popular approach in the recent English language teaching (ELT) in Indonesia. The curriculum underpinning ELT in the country has changed several times, although in the last 35 years its basis has been ...
Yenny Rahmawati
doaj   +1 more source

Listening skills instruction: practical tips for processing aural input [PDF]

, 2019
Two listening challenges faced by English L2 learners are (1) successfully identifying words in continuous speech and (2) understanding a speaker’s intended meaning. Listening is a skill L2 learners report wanting to improve, yet teaching practices often
Reed, Marnie
core  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Communicative English grammar teaching to high school learners in Vietnam

Ho Chi Minh City Open University Journal of Science - Social Sciences, 2017
In Vietnamese high schools, English is mainly delivered in grammar translation method to ameliorate student achievement in grammar-oriented examinations. In a long term, students suffer from fatigue and failure to communicate properly.
Khuong Thi Hong Cam
doaj  

A Comparison Of Adult- And Peer-Mediated Intervention For Autism: A Case Study [PDF]

, 2011
This study examined the response of a young child with autism to two play-based intervention conditions: adult-mediated and peer-mediated. The client was five years old, demonstrated moderate-to-severe autism, and exhibited developmental functioning ...
Moyle, Maura Jones
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Teachers’ Voices on the Challenges of the Implementation of Communicative Approach in Regards to the 2013 Curriculum

IJEE (Indonesian Journal of English Education), 2019
The Indonesian ELT current curriculum (the 2013 Curriculum) adopts communicative Approach (CA) as its basis foundation. Despite the fact that this approach has been adopted for some years, some research studies showed that it does not bring any ...
Yenni Rahmawati
doaj   +1 more source