Results 41 to 50 of about 468,708 (310)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Examining the cultural appropriateness of the communicative approach to language teaching in Japan. [PDF]

, 2018
The communicative approach has been one of the most successful and widely-used second language teaching approaches in the latter part of the twentieth century and the early stages of the twenty-first century.
Mathieson, Paul
core  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Why Communicative Approach Culturally Fails in Indonesia

Journal of Literature and Education
For decades, the Indonesian government has tried to catch up with the development of English language teaching worldwide. This paper discusses the implementation of the communicative approach (CA) and why it is culturally incompatible in Indonesia ...
Harits Masduqi, Fatimah Fatimah, Arif Subiyanto   +2 more
doaj   +1 more source

The Implementation of Communicative Language Teaching Approach in a Secondary School in Surabaya [PDF]

, 2014
This study is a qualitative study aimed to know the principles of CLT implemented and problems faced by a teacher in an English conversation class of eighth grades in S Secondary School. The data was taken through observation and interview.
Shinta, I. C. (Ina), Tedjaatmadja, H. M. (Herwindy)   +1 more
core  

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

THE MYTH ABOUT TRANSLATABILITY

Studia Universitatis Moldaviae: Stiinte Umanistice, 2020
Traditionally, (un)translatability is considered in linguistic theory of translation as an undesirable phenomenon caused by the use of units that do not have correspondences in the target language.
Vadim SDOBNIKOV
doaj  

ENCOURAGING CHILDREN IN LEARNING ENGLISH COMMUNICATIVELY BY USING SOME FUN ACTIVITIES IN THE CLASSROOM [PDF]

, 2012
This paper is talking about the interesting and fun way in teaching children as the young learner in English. It refers to an approach that is called the functional approach that focusesin the method of communicative language teaching.
Kusumaningrum , Sari
core  

Professionally-Oriented Communicative Language Teaching Approach by the Design of a Computer Assisted ESP Course: Analysis of Results [PDF]

, 2000
Professionally-Oriented Communicative Language Teaching is an effective approach widely recognized among scientists and teachers which involves learners in authentic environment and communication and helps develop communicative competence of non-native ...
Anastassiya A. Chernaya, Canale, Chernova, Ekaterina A. Golovacheva, Elvira Ya. Sokolova, Robert, Summaira Sarfraz   +6 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source