Results 21 to 30 of about 230,174 (213)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Mathematical modelling of community acquired antibiotic resistant infections

Informatics in Medicine Unlocked
Antibiotic usage in hospitals is considered the major driver of the emergence of antibiotic resistance where selection of multiply resistant strains is most common. However, massive antibiotic consumption occurs in the community. We formulate and analyse
Josiah Mushanyu
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Biomarkers in community-acquired pneumonia: A state-of-the-art review

Clinics, 2012
Community-acquired pneumonia (CAP) exhibits mortality rates, between 20% and 50% in severe cases. Biomarkers are useful tools for searching for antibiotic therapy modifications and for CAP diagnosis, prognosis and follow-up treatment. This non-systematic
Renato Seligman, Luis Francisco Ramos-Lima, Vivian do Amaral Oliveira, Carina Sanvicente, Elyara F Pacheco, Karoline Dalla Rosa   +5 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Drug resistance in community-acquired respiratory tract infections: role for an emerging antibacterial

Infection and Drug Resistance, 2010
Lorenzo Aguilar1, María-José Giménez1, José Barberán21Microbiology Department, School of Medicine, University Complutense, Madrid; 2Infectious Diseases Department, Hospital Central de la Defensa ...
Lorenzo Aguilar, María-José Giménez, José Barberán   +2 more
doaj  

Extended-Spectrum β-Lactamase and Carbapenemase-Producing Gram-Negative Bacteria and Associated Factors Among Patients Suspected of Community and Hospital-Acquired Urinary Tract Infections at Ayder Comprehensive Specialized Hospital, Tigrai, Ethiopia

Infection and Drug Resistance, 2023
Mulu Gebretsadik Gebremedhin,1 Yemane Weldu,2 Atsebaha Gebrekidan Kahsay,2 Gebrecherkos Teame,3 Kelemework Adane4 1Ayder Comprehensive Specialized Hospital, Mekelle University, Mekelle, Tigrai, Ethiopia; 2Department of Medical Microbiology and Immunology,
Gebremedhin MG, Weldu Y, Kahsay AG, Teame G, Adane K   +4 more
doaj  

Neutrophil-to-lymphocyte ratio: a potential supportive marker for elderly community-acquired bloodstream infections—a retrospective study [PDF]

PeerJ
Background Exploring the value of the neutrophil/lymphocyte ratio (NLR) as a potential supportive marker in community-acquired bloodstream infection in elderly patients.
Peijuan Li, Jiulin Zhang, Kun Chen, Qianqian Pei, Mengxi Ding, Chunmei Wang   +5 more
doaj   +2 more sources