Results 31 to 40 of about 419,828 (359)

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

The long Pentraxin PTX3 serves as an early predictive biomarker of co-infections in COVID-19Research in context

EBioMedicine
Summary: Background: COVID-19 clinical course is highly variable and secondary infections contribute to COVID-19 complexity. Early detection of secondary infections is clinically relevant for patient outcome.
Francesco Scavello, Enrico Brunetta, Sarah N. Mapelli, Emanuele Nappi, Ian David García Martín, Marina Sironi, Roberto Leone, Simone Solano, Giovanni Angelotti, Domenico Supino, Silvia Carnevale, Hang Zhong, Elena Magrini, Matteo Stravalaci, Alessandro Protti, Alessandro Santini, Elena Costantini, Victor Savevski, Antonio Voza, Barbara Bottazzi, Michele Bartoletti, Maurizio Cecconi, Alberto Mantovani, Paola Morelli, Federica Tordato, Cecilia Garlanda   +25 more
doaj   +1 more source

Chronic kidney disease as a risk factor for acute community-acquired infections in high-income countries: a systematic review. [PDF]

, 2014
OBJECTIVE: A systematic review of the association of predialysis chronic kidney disease (CKD) with the incidence of acute, community-acquired infections.
McDonald, Helen I, Nitsch, Dorothea, Thomas, Sara L   +2 more
core   +1 more source

Early Childhood Mortality from Community-acquired Infections [PDF]

American Journal of Epidemiology, 1999
In this study, the authors identified maternal and child characteristics that were independent predictors of death from infectious diseases acquired in the community and determined if these factors could be used to identify groups of children with excess risk of mortality from infection.
W O, Cooper, G B, Hickson, E F, Mitchel, K M, Edwards, P B, Thapa, W A, Ray   +5 more
openaire   +2 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Successful Treatment of Acute Prostatitis Caused by Multidrug-Resistant Escherichia coli With Tigecycline Monotherapy [PDF]

, 2020
We present a successful treatment, with tigecycline monotherapy, of acute prostatitis caused by multidrug-resistant Escherichia coli harboring an NDM-1 carbapemenase along with a CMY-2 cephalosporinase and a TEM ...
Babouee Flury, Baharak, Buetti, Niccolo, Casanova, Carlo, Furrer, Hansjakob, Jent, Philipp, Livermore, David M, Lo Priore, Elia, Pelzer, Niklas   +7 more
core   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

An Epidemiological Study on Legionnaires’ Disease in Gyeonggi Province, Korea: Occurrence, Infection Routes, and Risk Factors for Mortality (2016–2022)

Medicina
Background and Objectives: Legionnaires’ disease (LD) is an acute respiratory disease with increasing annual numbers of reported domestic and global cases.
Hae-Deun Noh, Jeonghyeon Oh, Kun-Hee Park, Boyoung Park   +3 more
doaj   +1 more source

Biomarkers in community-acquired pneumonia: A state-of-the-art review

Clinics, 2012
Community-acquired pneumonia (CAP) exhibits mortality rates, between 20% and 50% in severe cases. Biomarkers are useful tools for searching for antibiotic therapy modifications and for CAP diagnosis, prognosis and follow-up treatment. This non-systematic
Renato Seligman, Luis Francisco Ramos-Lima, Vivian do Amaral Oliveira, Carina Sanvicente, Elyara F Pacheco, Karoline Dalla Rosa   +5 more
doaj   +1 more source

Археологічна виставка Ніжинського краєзнавчого музею [PDF]

, 2009
Since the first description of the community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) strain USA300 [1] in the 1990s, this pathogen has emerged worldwide [2].
Bonten, M.J.M., Bootsma, M.C.
core   +1 more source