Results 81 to 90 of about 146,984 (316)

Community- versus nosocomial-acquired severe sepsis and septic shock in patients admitted to a tertiary intensive care in Saudi Arabia, etiology and outcome

Journal of Infection and Public Health, 2015
Summary: Background: Sepsis syndrome is a major worldwide cause of morbidity and mortality. While community-acquired severe sepsis and septic shock constitutes a major cause of admission to the intensive care unit, hospital-acquired severe sepsis and ...
Salim Baharoon, Ayman Telmesani, Hani Tamim, Eiman Alsafi, Sameerah Aljohani, Ebrahim Mahmoud, Hamdan Al-Jahdali   +6 more
doaj  

Aerobic bacteria study, clinical spectrum, and outcome of patients with community-acquired multidrug-resistant pathogens

Journal of Family Medicine and Primary Care
Context: Infectious diseases are the leading cause of death in developing countries like India. Hence, even small relative increases in the mortality rate for infections due to multidrug-resistant pathogens would lead to substantial increases in the ...
Chandra Sekhar Talari Sree, Ravi Shankar Calerappa, Geethanjali Anke   +2 more
doaj   +1 more source

Development of MDM2‐Targeting PROTAC for Advancing Bone Regeneration

Advanced Science, EarlyView.
This work presents a creative pipeline for developing MDM2‐targeting PROTACs (MDM2‐PROTACs) for application in bone regeneration. The developed PROTACs (CL144 and CL174) are validated for their degradation efficiency and osteogenic effects in human BMSCs.
Sol Jeong, Jae‐Kook Cha, Wasim Ahmed, Jaewan Kim, Minsup Kim, Kyung Tae Hong, Wonji Choi, Sunjoo Choi, Tae Hyeon Yoo, Hyun‑Ju An, Seung Chan An, Jaemin Lee, Jimin Choi, Sun‐Young Kim, Jun‐Seok Lee, Soonchul Lee, Junwon Choi, Jin Man Kim   +17 more
wiley   +1 more source

Higher incidence of perineal community acquired MRSA infections among toddlers

BMC Pediatrics, 2011
Background A six-fold increase in pediatric MRSA infections, prompted us to examine the clinical profile of children with MRSA infections seen at Mercy Children's Hospital, Toledo, Ohio and to characterize the responsible strains.
Blumenthal Robert M, Yogev Ram, Kabat William J, Haase Jeffrey, Zhao Xiaochen, Seifried Melissa, McCullough Alexis C, Mukundan Deepa   +7 more
doaj   +1 more source

Functional central limit theorems for epidemic models with varying infectivity [PDF]

arXiv, 2020
In this paper, we prove functional central limit theorems (FCLTs) for a stochastic epidemic model with varying infectivity and general infectious periods recently introduced in Forien, Pang and Pardoux (2020).The infectivity process (total force of infection at each time) is composed of the independent infectivity random functions of each infectious ...
arxiv  

Mechanisms of Baicalin Alleviates Intestinal Inflammation: Role of M1 Macrophage Polarization and Lactobacillus amylovorus

Advanced Science, EarlyView.
Baicalin alleviates E. coli‐induced intestinal inflammation through dual mechanisms: direct inhibition of the TLR4/IRF/STAT signaling pathway to modulate macrophage polarization and antigen presentation, thereby regulating Th17/Treg cell differentiation; and microbiota‐mediated indirect effects via increasing Lactobacillus amylovorus abundance and ...
Shunfen Zhang, Ruqing Zhong, Miao Zhou, Kai Li, Huiyuan Lv, Huixin Wang, Ye Xu, Dadan Liu, Qiugang Ma, Liang Chen, Hongfu Zhang   +10 more
wiley   +1 more source

SIS Epidemic Spreading with Heterogeneous Infection Rates [PDF]

arXiv, 2015
In this work, we aim to understand the influence of the heterogeneity of infection rates on the Susceptible-Infected-Susceptible (SIS) epidemic spreading. Employing the classic SIS model as the benchmark, we study the influence of the independently identically distributed infection rates on the average fraction of infected nodes in the metastable state.
arxiv  

Glycolysis‐Derived Lactate Induces ACSL4 Expression and Lactylation to Activate Ferroptosis during Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Glycolysis‐derived lactate activates nucleus pulposus cell ferroptosis via Histon H3K18la‐mediated ACSL4 transcription and ACSL4 lactylation and aggravate intervertebral disc degeneration. Inhibiting glycolysis via gene silencing or chemical intervention reduces the production of lactate and ameliorates ferroptosis activation and nucleus pulposus ...
Kaiqiang Sun, Yangyang Shi, Chen Yan, Shunmin Wang, Linhui Han, Fudong Li, Ximing Xu, Yuan Wang, Jingchuan Sun, Zijian Kang, Jiangang Shi   +10 more
wiley   +1 more source

Distribution and Epidemiological Characteristics of Clinical Isolates of A. fumigatus in a Hospital from 2021 to 2023: A Retrospective Study

Infection and Drug Resistance
Zhongqiu You,1,* Yunying Yan,2,* Tingting Fu,1 Xiao Yang,1 Zhirui Li,2 Lijun Zhou,2 Feng Zang3 1Department of Infection Management, Chengdu Pidu District People’s Hospital, Chengdu, Sichuan, 611730, People’s Republic of China; 2Department of ...
You Z, Yan Y, Fu T, Yang X, Li Z, Zhou L, Zang F   +6 more
doaj  

Decoding Blastocystis‐Driven Mechanisms in Gut Microbiota and Host Metabolism

Advanced Science, EarlyView.
Blastocystis, a prevalent gut microbe, interacts with the host through metabolic and immune pathways, influencing cardiometabolic health. This perspective explores its role in modulating short‐chain fatty acid production, tryptophan metabolism, and immune signaling, potentially impacting cholesterol absorption, glucose metabolism, and vascular health ...
Lei Deng, Kevin SW Tan
wiley   +1 more source