Results 31 to 40 of about 12,008,653 (299)
When Existing Jobs Don\u27t Fit: A Guide to Job Creation [PDF]
, 2004 [Excerpt] Successful job development for people with disabilities is about meeting the specific and often unique needs of each job seeker. Job creation is a way to modify or restructure existing jobs or bring together a combination of job tasks that fill
Institute for Community Inclusion
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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Research Involvement and EngagementBackground Parent-Child Interaction Therapy (PCIT) has been effectively implemented for autistic youth and their families who need help reducing disruptive behaviors, promoting language development, and enhancing the parent-child relationship.
Lauren Quetsch +3 more
doaj +1 more source
Minimum Wage Increase: What It Means for People with Disabilities [PDF]
, 2007 [Excerpt] The federal government has passed legislation that increases the minimum wage, the first increase in the national minimum wage in a decade.
Institute for Community Inclusion
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
More Than Just A Job: Person-centered Career Planning [PDF]
, 2003 [Excerpt] Person-Centered Career Planning is an approach to career development that helps people with disabilities develop and realize their dreams. It uses job seekers\u27 dreams, goals, personal preferences, interests, and needs as the cornerstone of ...
Institute for Community Inclusion
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Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Developing Community Partnerships to Reach Underserved Diverse Populations [PDF]
, 2005 [Excerpt] Like much of the U.S., Massachusetts is becoming increasingly racially and ethnically diverse. Studies show that the state’s future population growth will come through immigration. Meeting the needs of individuals with disabilities from diverse
Institute for Community Inclusion
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Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source