Results 51 to 60 of about 1,118,559 (301)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Innovations in higher education: Risks of using artificial intelligence tools

Цифровые модели и решения
n recent years, the artificial intelligence market has been growing rapidly. The paper aims to identify and analyse the risks arising from the use of artificial intelligence tools in higher education and to suggest ways of reducing these risks.
Marina B. Vidrevich, Irina V. Pervukhina, Mariya S. Turovskaya   +2 more
doaj   +1 more source

Introducing Decorated HODs: modeling assembly bias in the galaxy-halo connection

, 2015
The connection between galaxies and dark matter halos is often inferred from data using probabilistic models, such as the Halo Occupation Distribution (HOD).
Bosch, Frank C. van den, Campbell, Duncan, Hearin, Andrew P., Tollerud, Erik, Zentner, Andrew R.   +4 more
core   +1 more source

Communication: Microphase equilibrium and assembly dynamics [PDF]

The Journal of Chemical Physics, 2017
Despite many attempts, ordered equilibrium microphases have yet to be obtained in experimental colloidal suspensions. The recent computation of the equilibrium phase diagram of a microscopic, particle–based microphase former [Zhuang et al., Phys. Rev. Lett.
Yuan Zhuang, Patrick Charbonneau
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Species assembly in model ecosystems, II: Results of the assembly process [PDF]

, 2010
In the companion paper of this set (Capitan and Cuesta, 2010) we have developed a full analytical treatment of the model of species assembly introduced in Capitan et al. (2009).
Bastolla, Bastolla, Capitán, Case, Case, Cohen, Drake, Drossel, Dunne, Fukami, Hofbauer, Jordi Bascompte, José A. Capitán, José A. Cuesta, Karlin, Knuth, Law, Law, Levine, Lewis, McCann, Morton, Morton, Pimm, Pimm, Post, Roughgarden, Turelli, Virgo, Warren, Xie   +30 more
core   +6 more sources

Host effects on microbiota community assembly [PDF]

Journal of Animal Ecology, 2017
Abstract To what extent host‐associated microbiota assembly is driven by host selection or simply by happenstance remains an open question in microbiome research. Here, we take a first step towards elucidating the relative importance of host selection on the establishing gut microbial community in an ecologically relevant organism.
Kathrin Näpflin, Paul Schmid‐Hempel
openaire   +3 more sources

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Stochastic Assembly Leads to Alternative Communities with Distinct Functions in a Bioreactor Microbial Community

mBio, 2013
The processes and mechanisms of community assembly and its relationships to community functioning are central issues in ecology. Both deterministic and stochastic factors play important roles in shaping community composition and structure, but the ...
Jizhong Zhou, Wenzong Liu, Ye Deng, Yi-Huei Jiang, Kai Xue, Zhili He, Joy D. Van Nostrand, Liyou Wu, Yunfeng Yang, Aijie Wang   +9 more
doaj   +1 more source

Species-level functional profiling of metagenomes and metatranscriptomes. [PDF]

, 2018
Functional profiles of microbial communities are typically generated using comprehensive metagenomic or metatranscriptomic sequence read searches, which are time-consuming, prone to spurious mapping, and often limited to community-level quantification ...
A Sczyrba, A Shafquat, AE Duran-Pinedo, AK Sharma, B Buchfink, B Langmead, BE Suzek, BK Swan, C Burke, C Luo, Curtis Huttenhower, D Medini, DH Huson, DT Truong, DT Truong, E Pasolli, EA Franzosa, EA Franzosa, Eric A. Franzosa, George Weingart, GG Silva, Gholamali Rahnavard, H Hauswedell, J Kim, J Lloyd-Price, J Lloyd-Price, J Ravel, J. Gregory Caporaso, JA Fuhrman, K Huang, Karen Schwarzberg Lipson, Lauren J. McIver, LR Thompson, LR Thompson, Luke R. Thompson, M Hamady, M Kanehisa, M Scholz, Melanie Schirmer, MY Galperin, N Segata, N Segata, Nicola Segata, OU Mason, P Petrenko, PJ Turnbaugh, R Caspi, RC Edgar, RD Finn, Rob Knight, S Abubucker, S Nayfach, S Sunagawa, S Sunagawa, T Bose, UniProt Consortium., W Huang, Y Ye, Y Zhao   +58 more
core   +2 more sources