Results 71 to 80 of about 197,302 (301)

Using oocytes and embryos in ex-situ conservation of animal genetic resources (a review) [PDF]

Agroznanje, 2012
In the last few decades, farm animal genetic diversity has been rapidly declining. Therefore, it is in the interest of the international community to conserve livestock genetics.
Stančić Blagoje, Stančić Ivan, Jotanović Stoja, Šahinović Refik, Dragin Saša   +4 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Community Genetics in Developing Countries

Community Genetics, 2002
Accessible online at: www.karger.com/cmg To date, studies on human genetic disorders have mainly been conducted on populations living in developed countries, and the results reflect their contemporary disease profiles. An equivalent assessment of the impact of genetic disorders on the health of people in developing countries has not been possible ...
Bittles, A H, Savithri, H S, Rao, N Appaji   +2 more
openaire   +3 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Assessing parental understanding of variant reclassification in pediatric neurology and developmental pediatrics clinics

, 2021
Improvements in technology used for genetic testing have yielded an increased numbers of variants that are identified, each with a potential to return uninformative results.
Treat, Kayla, Margolin, Amy, Helm, Benjamin M., Prucka, Sandra K., Halverson, Colin M.E.   +4 more
core   +1 more source

United Arab Emirates: Communities and Community Genetics

Public Health Genomics, 2005
The UAE society is cosmopolitan, but the indigenous inhabitants are traditional with puritanical values despite their exposure to other vastly different cultures and habits. Marriages between consanguineous couples are still the norm rather than the exception. As a result, there is a high frequency of genetic disorders, particularly autosomal recessive
L I, Al-Gazali, R, Alwash, Y M, Abdulrazzaq   +2 more
openaire   +2 more sources

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

SYSGENET: a meeting report from a new European network for systems genetics [PDF]

, 2010
The first scientific meeting of the newly established European SYSGENET network took place at the Helmholtz Centre for Infection Research (HZI) in Braunschweig, April 7-9, 2010.
Andreux, P., null null, Arends, D., Balling, R., Schughart, K., Klaus Schughart, Schughart, Klaus, Prins, J.C.P.   +7 more
core   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

OBGYN providers’ lack of knowledge and management of genetic risks due to advanced paternal age underscore the need for updated practice guidance

, 2022
The objective of this pilot study was to characterize healthcare professionals’ knowledge of advanced paternal age (APA), the associated risks, as well as current clinical practices regarding APA.
Rouse, Caroline E., Geddes, Gabrielle C., Quirin, Kayla, Wetherill, Leah, Biddle, Joseph F., Hines, Karrie A.   +5 more
core   +1 more source