Results 61 to 70 of about 8,457,156 (308)

Storylines of family medicine II: foundational building blocks-context, community and health

Storylines of Family Medicine is a 12-part series of thematically linked mini-essays with accompanying illustrations that explore the many dimensions of family medicine, as interpreted by individual family physicians and medical educators in the USA and ...
Geoffrey M Gusoff, Shah, Rupal, Richard M Frankel, Ventres, William B., A Peter Catinella, Winston Liaw, Bich-May Nguyen, Like, Robert C., Teresa L Schiff-Elfalan, Carter, Tamala, Stone, Leslie A., Zoppi, Kathleen, Frankel, Richard M., Mary Alice Scott, Nguyen, Bich-May, Gusoff, Geoffrey M., William B Ventres, Rachelson, Joanna V., Yamada, Seiji, Rupal Shah, Kathleen Zoppi, Tamala Carter, Liaw, Winston, Shailendra Prasad, Scott, Mary Alice, Schiff-Elfalan, Teresa L., Prasad, Shailendra, Seiji Yamada, Catinella, A. Peter, Joanna V Rachelson, Leslie A Stone, Robert C Like   +31 more
core   +1 more source

Lower urinary tract symptoms and quality of life in community-dwelling individuals aged 45 years and over. A population-based study

Acta Scientiarum. Health Sciences, 2019
The objective of this study was to identify the factors associated with the impairment of quality of life (QoL) in community-dwelling individuals with LUTS.
Carlos Augusto Faria, Dayse Mary da Silva Correia, Karen Soto Perez Panisset, Maria Luiza Garcia Rosa   +3 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Boston University School of Medicine catalog [PDF]

, 1873
Course catalog and informational material for the Boston University School of ...
Boston University School of Medicine
core  

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Procedures in emergency medicine: oropharyngeal airway insertion

, 2013
This video is part of a series of videos demonstrating common procedures performed in the Emergency Medicine setting. It was prepared by Cape Town Emergency Medicine's consultants and registrars. This short simulated video demonstrates the technique of
Oosthuizen, Almero, Cape Town Emergency Medicine Registrars   +1 more
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source